期刊文献+

维生素E衍生物生育三烯酚抗肿瘤分子机制的研究进展 被引量:4

下载PDF
导出
摘要 维生素E是一种具有抗氧化作用的脂溶性维生素,由两大类结构近似的化合物组成:生育酚(tocopherols)和生育三烯酚(tocotrienols)。近年来的文献报道,生育三烯酚具有较强的抗肿瘤活性,可以在体外及体内抑制肿瘤细胞增殖,诱导肿瘤细胞凋亡,具有很好的临床应用前景。因此,我们对生育三烯酚抑制肿瘤生长及相关分子机制的一些文献进行综述,为其未来在肿瘤临床治疗中的应用提供理论依据。
作者 王忱 佟仲生
出处 《实用医学杂志》 CAS 北大核心 2016年第14期2410-2412,共3页 The Journal of Practical Medicine
基金 国家自然科学基金青年项目(编号:81302080) 天津市抗癌重大专项基金(编号:12ZCDZSY16200)
  • 相关文献

参考文献22

  • 1BEHERY FA, AKL MR, ANANTHULA S, et al. Optimization of tocotrienols as antiproliferative and antimigratory leads [J]. Eur J Med Chem, 2013,59:329-341.
  • 2YANO T, SATO A, SEKINE M, et al. Redox-inactive analogue of tocotrienol as a potential anti-cancer agent [J]. Anticancer Agents Med Chem, 2013, 13(3) :496-501.
  • 3LING MT, LUK SU, AL-EJEH F, et al. Tocotrienol as a potential anticancer agent [J]. Carcinogenesis, 2012,33 (2) :233-239.
  • 4宋玉玲,刘长梅.NF-κB与甲状腺癌的研究进展[J].实用医学杂志,2014,30(22):3673-3674. 被引量:3
  • 5AB, SUNG B, RAVINDRAN J, et al {Gammal-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment [J]. Cancer Res, 2010,70(21 ) : 8695-8705.
  • 6KANNAPPAN R, RAVINDRAN J, PRASAD S, et al. Gamma- tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53- mediated upregulation of death receptors [J]. Mol Cancer Ther, 2010, 9(8) :2196-2207.
  • 7HUSAIN K, FRANCOIS RA, YAMAUCHI T, et al. Vitamin E 8-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-KB activation in pancreatic cancer [J]. Mol Cancer Ther, 2011,10(12) : 2363-2372.
  • 8COLLINS MA, BEDNAR F, ZHANG Y, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice [ J ]. J Clin Invest, 2012,122 ( 2 ), 639-653.
  • 9YING H, KIMMELMAN AC, LYSSIOTIS CA, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism [J]. Cell, 2012,149(3), 656-670.
  • 10HUSAIN K, CENTENO BA, CHEN DT, et al. Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+ ; Pdx-l-Cre mice by vitamin E 8-tocotrienol [J]. Carcinogenesis, 2013,34(4) : 858-863.

二级参考文献22

  • 1陈莉颖,陈红风,付娜,叶媚娜.218例不同分子亚型浸润性乳腺癌患者的临床特征[J].现代肿瘤医学,2007,15(8):1094-1097. 被引量:12
  • 2Zhu H, Bhaijee F, Ishaq N, et al.Correlation of Notchl.pAKT and nuclearNF-KB expression in triple negativebreast cancer [J]. Am J Cancer Res,2013,3(2):230-239.
  • 3Storz P. Targeting the alternative NF-KBpathway cancer : a new direction fortherapy [J]. Expert Rev AnticancerTher,2013,13(5) :501-504.
  • 4Rushworth SA, Zaitseva L, MurrayMY, et al. The high Nrl2 expression inhuman acute myeloid leukemia is drivenby NF-KB and underlies its chmo-resistance [J]. Blood,2012,120 (26):5188-5198.
  • 5American Thyroid Association (ATA)Guidelines Taskforce on ThyroidNodules and Differentiated ThyroidCancer. Cooper DS. Doherty GMRevised American Thyroid Associationmanagement guidelines for patients withthyroid nodules and differentiatedthyroid cancer [J]. Thyroid, 2009, 19:1167-1214.
  • 6Sen R, Baltimore D. Multiple nuclearfactors interact with the immunoglobulinenhancer senquences [J]. Cell, 1986,46(5):705-716.
  • 7Hayden MS, Ghosh S. Sharedprinciples in NF-kappaB signaling [J].Cell, 2008,132(3), 344-362.
  • 8Chen W, Li Z, Bai L, et al. NF-kappaB in lung cancer,a carcinogenesismediator and a prevention and therapytarget [J]. Front Biosci ,2011,16:1172-1185.
  • 9Pacific.F, Mauro C, Barone C.Oncogenic and anti-apoptotic activity ofNF-kappa B in human thyroidcarcinomas [J]. J Biol Chem, 2004,279(52):54610-54619.
  • 10Didonato JA, Mercurio F,Karifl M.NF-kB and the link betweeninflammation and cancer [J].ImmunolRev,2012,246(1):379-400.

共引文献19

同被引文献93

引证文献4

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部