血管内皮细胞生长因子靶向治疗急性髓系白血病的研究进展

Progresses of vascular endothelial growth factor as a target for acute myeloid leukemia therapy

目的VEGF是调节血管形成的关键，在急性髓系白血病的发生发展中起着重要作用，随着对抗肿瘤血管形成的认识，研究者们以VEGF及其受体为靶点，不断探索新的药物，现从VEGF的生物学特性、靶向治疗急性髓系白血病的特点及临床应用的研究进展综述如下。

Objective Vascular endothelial growth factor（VEGF） is the key to regulat vascularization, and plays an important role in the development of acute myeloid leukemia. With the understanding of anti-tumor angiopoiesis, researchers take VEGF and its receptors as targets, continuously exploring the new drug. We summarized the biological characteristics of VEGF, vascular-targeted therapy and the clinical application of drugs.