多巴胺受体激动剂在帕金森病治疗中的剂量与疗效关系探讨

Dopamine receptor agonists investigate relationship between dose and efficacy in the treatment of Parkinson ＇s disease

目的：临床探讨多巴胺受体激动剂（盐酸普拉克索）在帕金森病治疗中的剂量与疗效关系，旨在为提升临床治疗效果提供参考。方法：将研究对象随机分为三组（各20例），其中A组给予单纯服用盐酸普拉克索，B组在服用多巴丝肼基础上加服盐酸普拉克索，C组在服用吡贝地尔、多巴丝肼后将吡贝地尔替换为盐酸普拉克索，比较分析治疗前、后帕金森评定量表（UPDRS）指标数据差异性，以此评估临床疗效。结果：三组患者给予服用盐酸普拉克索后UPDRS均值均低于基线（P〈0．05），其中A组患者的UPDRSI总评分与基线无明显差异性（P〉0．05），而UPDRSⅡ、Ⅲ总评分与基线比较差异具有统计学意义（P〈0．05）；B、C组患者的UPDRSI、Ⅱ、Ⅲ总评分与基线比较差异具有统计学意义（P〈0．05），而UPDRS1V总评分与基线无明显差异性（P〉0．05）。结论：经临床研究证实，单用盐酸普拉克索治疗PD疗效确切，而随着增加服用盐酸普拉克索剂量治疗后患者的非运动、运动症状改善明显，表明盐酸普拉克索剂量大小与帕金森患者的情绪、精神及行为改善有关，但是与治疗并发症无关。

OBJECTIVE： To explore the relationship between dise and effect of dopamine agonists pramipexole （hydrochloric acid） in the treatment of Parkinson＇ s disease in order to improve the clinical therapeutic effect. METHODS ： The Patients selected were divided into three groups （20 cases each group）. Group A received hydrochloric acid pramipexole, group B, on the basis of taking dopamine silk hydrazine, took hydrochloride pramipexole, and group C, after taking bei er and dopamine silk hydrazine pyrazole, bei to was replaced by hydrochloric acid pramipexole. Before and after treatment UPDRS diversity index data was compared to evaluate the clinical curative effect. RESULTS ： After taking hydrochloric acid pramipexole UPDRS average in the three groups were significantly lower than baseline （ P 〈 O. 05 ）. There was no significantly difference in UPDRS I total score and the baseline in group A （ P 〉 0. 05 ）. But there were statistically significant in the UPDRS Ⅱ、Ⅲ total score compared with the baseline （ P 〈 0. 05 ） ; There was statistically singificant difference in UPDRS I , Ⅱ、Ⅲ total score compared with the baseline in group B and groupC （P 〈0. 05）, while in the UPDRS IV total score and the baseline. There was no obviously difference （P 〉 0. 05 ）. CONCLUSION：Pramipexole hydrochloride can treat PD effectinely. And with the increasing dose of hydrochloric acid pramipexole in the treatment of the patients after the movement the symptoms were improved significantly, which shows that hydrochloric acid pramipexole doses are related with emotional, mental and behavior of the patients with Parkinson＇ s disease.