摘要
目的：探讨原发性高血压患者的血压水平与早期肾损害的相关性。方法：选取2014年7月～2015年6月于本院内科就诊的60例原发性高血压患者，对上述患者进行尿微量白蛋白（mAlb）含量分析，以mAlb为早期肾损害的诊断指标，根据检测结果将上述患者分为研究组和对照组，同时检测两组患者的脉压（PP）、平均动脉压（MAP）、收缩压（SBP）、舒张压（DBP）、大动脉弹性（c1）、肱-踝脉搏波传导速度（baPWV）等指标的变化，并分析上述指标和早期肾损害的相关性。结果：高血压患者的分级越高，mAlb的阳性率越高；研究组患者PP、SBP、DBP、C1、baPWV值与对照组相比有明显变化，差异有统计学意义（P〈0．05）；除c1外，上述血压指标均与mAlb呈正相关，c1与mAlb呈负相关。结论：原发性高血压患者的PP、SBP、DBP、baPWV、MAP越高、c1越低，其早期肾损害越严重；另外，随着患者高血压等级的逐渐升高，其早期肾损害情况也逐渐加重，临床上应对上述患者多加关注。
OBJECTIVE ： To discuss the relationship between blood pressure levels and early renal damage in the patients with es- sential hypertension. METHODS： 60 patients with essential hypertension were choosed in our hospital from July 2014 to June 2015. The urinary albumin （mAlb） content was analysed and mAlb were diagnosis index of early renal damage. According to test results the above patients were divided into study group and control group. In the two groups pulse pressure （PP）, mean arterial pressure （MAP）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, the main artery elasticity （C1）, brachial -changes an- kle pulse wave velocity （baPWV） and other indicators were detected. And the relation between these indicators and early kidney dam- age were analyzed. RESULTS： ①The higher the grade was, the higher the positive rate of mAlb in the patients with hypertension was; ②There were significant difference in PP, SBP, DBP, C1 and baPWV in study group compared with the control group （P 〈 0. 05 ） ; ③In addition to C1, the above indicators blood pressure were positively correlated to mAlb and there was the negative correla- tion between C1 and mAlb. CONCLUSIONS： PP, SBP, DBP, baPWV, MAP, and C1 were higher in the patients with essential hypertension and the early renal damage was more serious. In addition, with the gradual increment of hypertension in the patients, the early renal damage gradually increases. These patients should be paid more attention to.
出处
《国际老年医学杂志》
2016年第4期155-158,共4页
International Journal of Geriatrics
基金
河北省中医药学会项目（20151782）
