木香养胃颗粒对大鼠慢性萎缩性胃炎治疗作用的实验研究

Experimental Study on Therapyeutic Effect of Muxiang Yangwei Granule(木香养胃颗粒) on Rats with Chronic Atrophic Gastritis

目的:观察木香养胃颗粒对大鼠慢性萎缩性胃炎的治疗作用。方法:90只大鼠随机分为6组,正常对照组,模型对照组,三九胃泰组,木香养胃颗粒低、中、高剂量组。大鼠分别连续给予0.02%氨水17 W、20 mmol/L脱氧胆酸钠13 W制备大鼠慢性萎缩性胃炎模型,各组大鼠连续给予相应处理4 W。观察各组大鼠胃黏膜炎症浸润程度及胃黏膜高度变化;检测胃液中胃蛋白酶及血清中胃泌素含量。结果:与正常组比较,模型组大鼠胃黏膜明显变薄(P<0.05,P<0.01),胃黏膜炎症浸润明显(P<0.01),血清胃泌素含量明显升高,胃液中胃蛋白酶含量明显降低(P<0.05);木香养胃颗粒组胃黏膜高度明显增加(P<0.05),炎症浸润明显减轻(P<0.05),胃液中胃蛋白酶含量明显增高(P<0.01),血清胃泌素含量明显降低(P<0.05)。结论:木香养胃颗粒对慢性萎缩性胃炎大鼠胃黏膜损伤具有明显的保护作用,明显促进胃消化液分泌,调节胃泌素分泌。

Objective： To observe the therapeutic effect of Muxiang Yangwei Granules on rats with chronic atrophic gastritis. Methods： 90 Rats were divided into 6 groups at random,normal,model,Sanjiu Weitai Granule（三九胃泰颗粒） positive group,Muxiang Yangwei Granule low,middle and high dose groups. Models of atrophic gastritis were established by continuously given 0. 02% ammonia solution for 17 weeks and 20 mmol / L sodium deoxycholate for 13 weeks. Each group was given the corresponding medicine or saline for 4 weeks from the thirteenth week of modeling. Gastric mucosal inflammation infiltration degree and gastric mucosal changes in height were observed,pepsin of gastric juice serum gastrin content were determined. Results： To compare with normal group,gastric mucosa of rats in model group became thin（ P〈0. 05,P〈0. 01） and gastric mucosal inflammation invasion was significant（ P〈0. 01）,pepsin of gastric juice was obviously reduced,serum gastrin content was raised; The gastric mucosal height of rats in Muxiang Yangwei Granule groups increased（ P〈0. 05）,inflammatory infiltration significantly reduced（P〈0. 05）,gastric juice pepsin content increased significantly（ P〈0. 01）,content of serum gastrin decreased significantly（ P〈0. 05）. Conclusion： Muxiang Yangwei Ganules can effectively protect gastric mucosa of chronic atrophic gastritis rats from injury,significantly promote gastric secretion of digestive juice,regulate gastrin secretion.