热毒宁联合阿奇霉素对支原体肺炎患儿炎性因子及临床疗效的影响

Effect of Reduning combined with azithromycin on inflammatory factors and clinical efficacy in children with mycoplasma pneumonia

目的探讨热毒宁联合阿奇霉素对支原体肺炎(MP)患儿炎性因子及临床疗效的影响。方法将MP患儿80例分为观察组和对照组各40例。所有患儿均给予常规治疗,对照组采用阿奇霉素治疗,观察组在对照组的基础上采用热毒宁治疗,比较两组治疗前后炎性因子的变化、治疗有效率、症状恢复情况以及不良反应的发生情况。结果观察组治疗总有效率为97.5%,显著高于对照组的82.5%(P<0.05)。观察组患者的发热、肺啰音、咳嗽消失所需时间及住院时间均显著短于对照组(P<0.05)。观察组治疗后的白细胞介素(IL)-10、IL-6水平低于对照组,肿瘤坏死因子(TNF)-α水平高于对照组(P<0.05)。观察组的不良反应发生率为5.00%,低于对照组的10.00%,但两者比较,差异无统计学意义(P>0.05)。结论热毒宁注射液联合阿奇霉素能够显著提高MP患儿的临床疗效、缩短康复时间,这可能与热毒宁和抗生素结合应用可增强抗炎作用及调节免疫功能有关。

Objective To investigate the effect of Reduning combined with azithromycin on inflammatory factors and clinical efficacy in children with mycoplasma pneumonia. Methods Eighty children with mycoplasma pneumonia were divided into observation group and control group,with 40 cases in each group. All patients were given conventional treatment. The control group was treated with azithromycin, and the observation group with Reduning on the basis of the treatment performed in the control group. The changes of inflammatory factors, therapeutic effective rate, symptom recovery and the incidence of adverse reactions were compared between the two groups before and after treatment. Results The total effective rate in the observation group was 97.5% ,and was significantly higher than that in the control group （82.5% ,P 〈0.05）. The durations of fever,pulmonary rales and cough disappearing,and hospital stay in the observation group were shorter than those in the control group（P 〈0. 05）. After treatment,the levels of interleukin（ IL）-10 and IL-6 were lower and the level of tumor necrosis factor（TNF） -α was higher in the observation group compared to the control group （P 〈 0.05 ）. The incidence of adverse reactions in the observation group was 5.00% ,and was lower than that in the control group（ 10.00% ） ,but there was no statistical difference between the two groups （P 〉 0.05）. Conclusion Reduning injection combined with azithromycin can significantly improve the clinical efficacy and shorten the recovery duration in children with mycoplasma pneumonia,which may be related with anti-inflammatory and immunomodulatory effect enhanced by Reduning combined with antibiotics.