雾化吸入防治鼻咽癌放射性口咽损伤的时机

Time of aerosol inhalation on prevention of pharyngeal and oral mucosa damage induced by radiotherapy in nasopharyngeal carcinoma

目的：观察吸入用布地奈德混悬液加沐舒坦（盐酸氨溴索）氧气驱动雾化吸入治疗防治鼻咽癌放疗所致咽部损伤的时机。方法108例鼻咽癌患者分为4组，每组27例。3个治疗组分别在放疗初始、放疗5次后、放疗10次后以布地奈德混悬液＋沐舒坦氧气驱动雾化吸入治疗；对照组未予雾化吸入治疗。比较各组在不同放疗剂量时咽部黏膜III度损伤情况。结果照射剂量在30 Gy以下时，3个治疗组均无III度咽部黏膜损伤发生，对照组1例。在30～40 Gy时，3个治疗组及对照组均有III度黏膜损伤，组间无统计学意义。照射计量达40 Gy以上，治疗1组、治疗2组III度黏膜损伤低于对照组，差异有显著性。治疗3组与对照组比较差异无显著性。结论鼻咽癌放疗5～10次，以布地奈德混悬液＋沐舒坦氧气驱动雾化吸入治疗可减轻放疗所致咽部损伤，且为较好时机。

OBJECTIVE To investigate the time＆amp;nbsp;of aerosol inhalation using Budesonide Suspension and Mucosolvan drived by oxygen on prevention of pharyngeal and oral mucosa damage induced by radiotherapy in nasopharyngeal carcinoma （NPC）. METHODS All 108 cases with NPC were divided into 4 groups, each group 27 cases. In 3 treatment groups,aerosol inhalation using Budesonide Suspension and Mucosolvan drived by oxygen were began at the initial , after 5 times, after 10 times radiotherapy respectively. In control group, aerosol inhalation was not used. The rates of third degree of pharyngeal and oral mucosa injury during different dose of radiotherapy were compared among the 4 groups. RESULTS At the dose below 30 Gy, there were no case of third degree of pharyngeal and oral mucosa injury occurred in 3 treatment groups, one case in control group. At the dose of 30 to 40 Gy, third degree injury occurred in all groups, there was no statistical difference among the 4 groups. At the dose over 40 Gy, the patients of third degree injury in group 1 and 2 were less than that in control group. There was no difference between group 3 and control group. CONCLUSION The right time of aerosol inhalation using Budesonide Suspension and Mucosolvan drived by oxygen for prevention of pharyngeal and oral mucosa complication induced by radiotherapy in NPC is at 5 to 10 times after radiotherapy.