辛伐他汀的不良反应及与其他药物的相互作用分析

Analysis of Adverse Drug Reactions of Simvastatin And Its Interaction With Other Drugs

目的分析辛伐他汀的不良反应及与其他药物的相互作用。方法筛选医院2013年2月至2015年4月门诊开具的辛伐他汀不良反应事件处方,分析其不良反应表现及与其他药物的相互作用。结果共搜集涉及辛伐他汀的不良反应处方168张,不良反应以肌无力、横纹肌溶解、肝损害、多尿等为主要表现,并累及多个系统,主要集中在神经肌肉系统(34.52%)、肝肾系统(20.83%)、皮肤系统(15.48%)等。不良反应患者中,辛伐他汀用药20 mg/d比例最高(58.93%),其次为10 mg/d(17.86%)。168张不良反应处方中,因药物相互作用引起的共41张,其中大环内酯类联用比例最高(56.01%),其次为烟酸(17.07%)。结论辛伐他汀使用不当易出现不良反应,开处方时需根据实际情况,合理调整剂量及选择配伍药物。

Objective To analyze the adverse drug reactions（ ADR） of simvastatin and its interaction with other drugs. Methods ADR events in the hospital clinic from February 2013 to April 2015 were screened,the ADR were analyzed,and simvastatin＇s interactions with other drugs was statistical analysis. Results Simvastatin＇s ADR were collected from 168 co- prescriptions,and the ADR mainly manifested as muscle weakness,rhabdomyolysis,liver damage,and diuresis. The ADR usually involved multiple systems,mainly in the neuromuscular system（ 34. 52%）,liver and kidney systems（ 20. 83%）,skin（ 15. 48%） etc. Cases of adverse reactions,the drug simvastatin 20 mg / d had the highest percentage（ 58. 93%）,followed by 10 mg / d（ 17. 86%）. In the 168 prescriptions of ADR,ADR due to drug interactions led to a total of 41,in which erythromycin combination had the highest percentage（ 56. 01%）,followed by nicotinic acid drugs（ 17. 07%）. Conclusion Improper use of simvastatin prone to ADR,prescription needs to be based on the actual situation,a reasonable adjustment of the dose,choose a reasonable combination of drugs.