期刊文献+

局部溶栓联合贝前列素治疗肺栓塞合并肺动脉高压症 被引量:1

Efficacy of Local Thrombolysis Combined with Beraprost in Patients with Pulmonary Embolism Complicated by Pulmonary Arterial Hypertension
下载PDF
导出
摘要 目的 探析局部溶栓联合贝前列素对肺栓塞合并肺动脉高压患者的疗效及出血风险。方法 选择我院2011年4月~2015年4月收治的103例肺栓塞合并肺动脉高压患者作为研究对象,随机数字表法分为观察组(n=52)与对照组(n=51)。对照组采取全身溶栓联合贝前列素进行治疗,观察组采取局部溶栓联合贝前列素进行治疗,比较两组治疗有效率、治疗前后D二聚体(D-D)与一氧化氮(NO)的变化及并发症发生率。结果 观察组治疗总有效率为96.2%(50/52),对照组为84.3%(43/51),观察组明显更高,差异有统计学意义(P〈0.05)。两组治疗前D-D与NO的差异无统计学意义(P〉0.05),治疗后两组的D-D与NO水平均获得改善,组内前后差异均有统计学意义(P〈0.05),同时观察组治疗后的D-D与NO水平均低于对照组,组间差异有统计学意义(P〈0.05),提示观察组D-D与NO指标改善幅度更大。两组并发症均以心率失常、胸腔积液、出血为主,其中观察组为7.6%(4/52),对照组为23.5%(12/51),其中两组心律失常与胸腔积液发生率接近,但观察组出血发生率低于对照组,差异有统计学意义(P〈0.05)。结论 局部溶栓联合贝前列素为肺栓塞合并肺动脉高压患者的有效治疗方案,疗效满意,且安全性高。 Objective To explore the efficacy of local thrombolysis combined pulmonary embolism complicated by pulmonary arterial hypertension and bleeding beraprost in patients with risk. Methods 103 pa- tients with pulmonary embolism complicated by pulmonary arterial hypertension treated in our hospital from A- pril 2011 to April 2015 were selected as the research objects. According to the random number table method, the patients were divided into the observation group (n = 52 )and the control group( n = 51 ). The control group was treated with systemic thrombolysis combined with beraprost, while the observation group was treated with local thrombolysis combined with beraprost. The effective rates, D- dimer ( D- D ) and nitric oxide ( NO ) before and after the treatment and the incidence of complications were compared between the two groups. Results The total effective rate of the observation group [ 96.2% (50/52) ] was significantly higher than that of the con- trol group [ 84. 3 % (43/51 ) ] ( P 〈 0. 05 ). Before treatment, there were no significant differences of D- D and NO between the two groups ( P 〉 0. 05 ). After treatment, the levels of D- D and NO in the two groups were im- proved. The before and after differences within group were statistically significant (P 〈 0. 05 ). Meanwhile, the levels of D- D and NO in the observation group after the treatment were lower than those in the control group ( P 〈 0. 05 ), which indicated that the improvement of D- D and NO in the observation group was more signifi- cant. The main complications of the two groups were arrhythmia, pleural effusion and bleeding. The incidence of complications in the observation group was 7.6% (4/52) while in the control group was 23.5% ( 12/51 ). The incidence rates of arrhythmia and pleural effusion in the two groups were close, but the incidence of bleed- ing in the observation group was lower than that in the control group (P 〈 0. 05 ). Conclusion Local throm- bolysis combined with beraprost is an effective treatment for patients with pulmonary embolism complicated by pulmonary arterial hypertension. The efficacy is satisfying and the safety is higher.
出处 《血栓与止血学》 2016年第3期273-275,共3页 Chinese Journal of Thrombosis and Hemostasis
关键词 肺栓塞 肺动脉高压 局部溶栓 贝前列素 Pulmonary embolism Pulmonary arterial hypertension Local thrombolysis Bera- prost
  • 相关文献

参考文献7

二级参考文献68

  • 1荆志成.2010年中国肺高血压诊治指南[J].中国医学前沿杂志(电子版),2011,3(2):62-81. 被引量:117
  • 2杨玲,王佳,林建海.急性肺栓塞性肺高压局部溶栓和全身溶栓的比较[J].中华急诊医学杂志,2005,14(5):402-404. 被引量:8
  • 3陆慰萱.肺动脉高压的新分类[J].中国实用内科杂志,2006,26(1):60-62. 被引量:12
  • 4Singh TP,Rohit M,Grover A,菅鑫妍.口服西地那非疗法治疗严重肺动脉高压的效果研究[J].中国处方药,2006(8):29-29. 被引量:49
  • 5Dantzker DR, Bower JS. Mechanisms of gas exchange abnormality in patients with chronic obliterative pulmonary vascular disease. J Clin Invest, 1979,64 : 1050-1055.
  • 6Naeije R, Melot C, Mols P, et al. Effects of vasodilators on hypoxic pulmonary vasoconstriction in normal man. Chest, 1952,52:404-410.
  • 7Rich S, Martinez J, Lam W, et al. Reassessment of the effects vasodilator drugs in primary pulmonary hypertension. Guidelines for determining a pulmonary vasodilator response. Am Heart J, 1983,105:119- 127.
  • 8Rich S, Dentzker DR, Ayres SM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med, 1987,107:216- 223.
  • 9Badesch, MDa Y, Akutsu H, et al. Long term favorable effect of oxygen administration on a patient with primary pulmonary hypertension. Chest,1978,74:299.
  • 10McLaughlin VV, Archerm SL, Badescll DB, et al. ACCF/AHA 2009 Expert consensus document on pulmanary hypertension. J Am Coll Cardial,2009,53 : 1573-1619.

共引文献1882

同被引文献7

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部