原位再生医疗技术治疗外伤性甲床缺损的疗效观察

Clinical Efficacy Observation of the In Situ Regenerative Medical Technology in the Treatment of Traumatic Nail Bed Defect

目的探讨原位再生医疗技术治疗外伤性甲床缺损的临床疗效。方法将1997年以来青岛市黄岛区人民医院收治的60例外伤性甲床缺损患者（65根手指）简单清创后,直接涂抹湿润烧伤膏（Moist Exposed Burn Ointment,MEBO）治疗,每4~6 h换药1次,观察治疗效果,并与随机抽取的同期本院西医手术治疗的60例患者（62根手指）疗效进行对比。结果原位再生医疗技术治疗的65根手指,优58根（89.23%）、良5根（7.69%）、可2根（3.08%）,总优良率为96.92%;西医手术治疗的62根手指,优18根（29.03%）、良9根（14.52%）、可21根（33.87%）、差14根（22.58%）,总优良率为43.55%,两组对比,P〈0.01,差异具有统计学意义。结论原位再生医疗技术治疗外伤性甲床缺损,能够原位再生出新指甲,完好地保留手指的长度和功能,疗效显著,值得临床推广应用。

Objective To study the clinical efficacy of the in situ regenerative medical technology in the treatment of traumatic nail bed defect.Methods Sixty patients with traumatic nail bed defect（65 fingers involved）admitted into the Huangdao People＇s Hospital,Qingdao,since the year of 1997 were treated with Moist Exposed Burn Ointment（MEBO Ointment） directly after the simple debridement,and the dressing was changed every 4-6 hours.The treatment efficacy was observed and compared with that of 60 patients（62 fingers involved） randomly selected and treated with the surgical method of western medicine in the same hospital and at the same time period.Results Of the 65 fingers receiving the treatment of the in situ regenerative medical technology,58 fingers（89.23%） realized excellent curative effect,5 fingers（7.69%） good curative effect and 2 fingers（3.08%） average curative effect,with the total excellent and good rate being96.92%;while of the 62 fingers receiving the treatment of the western surgical method,18 fingers（29.03%） got excellent curative effect,9 fingers（14.52%） good curative effect,21 fingers（33.87%） average curative effect and 14 fingers（22.58%） poor curative effect,with the total excellent and good rate being 43.55%.There was statistically significant difference between the two groups（P〈0.01）.Conclusion The in situ regenerative medical technology in the treatment of traumatic nail bed defect can realize significant curative effect,such as helping in situ regenerate new nails and restoring the finger length and function completetly,deserving to be promoted and popularized in clinic.