血小板输注治疗血液病患者的疗效及相关影响因素的分析

Analysis of the Relationship Between the Curative Effect of Platelet Transfusion in the Treatment of Patients with Hematologic Diseases and the Related Influencing Factors

目的探析血小板输注治疗血液病患者的疗效并对相关影响因素进行分析。方法收集于2012年1月到2015年8月来我院进行血小板输注的患者62例作为研究对象,均予以血小板输注治疗,比较患者输注血小板前后的PPR(血小板回收率)、CCI(血小板计数增高指数)。围绕性别、年龄、合并感染、脾肿大及弥散性血管内凝血等因素进行分析,明确以上因素是否对血小板输注有效性造成影响。结果患者血小板输注后,1 h的CCI及PPR与24 h的CCI及PPR均分别高于输注前,差异有统计学意义(P<0.05)。四种类型患者中,ITP的血小板输注失效率最高,达51.22%,分别高于AL、AA,差异有统计学意义(P<0.05),其次为MDS,同样高于AL、AA,但差异无统计学意义(P>0.05)。性别、年龄对血小板输注的疗效无明显影响,但合并感染、脾肿大及弥散性血管内凝血患者中血小板输注输注失效率明显高于未合并患者,差异有统计学意义(P<0.05)。结论血小板输注治疗血液病患者具有较好疗效,为进一步提高治疗有效性,需消除感染、脾肿大、弥散性血管内凝血等因素的影响。

Objective To explore the curative effect of platelet transfusion in the treatment of patients with hematologic diseases and to analyze the related influencing factors. Methods 62 patients who received platelet transfusion in our hospital from January 2012 to August 2015 were taken as the research objects and were treated by platelet transfusion therapy. PPR （ percentage of plate recovery） and CCI （ corrected count in- crement） before and after platelet transfusion were compared. The factors such as gender ,age ,concurrent infec- tion, splenomegaly and disseminated intravascular coagulation were analyzed to clarify whether the above fac- tors affected the effectiveness of platelet transfusion. Results After platelet transfusion, the 1-hour and 24- hour CCI and PPR were significantly higher than those before platelet transfusion（P 〈 0. 05 ）. Among the four types of patients, the failure rate of platelet transfusion of ITP was the highest（51.22% ）and was respectively higher than that of AL and AA （P 〈 0. 05 ）, followed by MDS which was also higher than that of AL and AA but the differences were not statistically significant （ P 〉 0. 05 ）. Gender and age had no significant effect on the curative effect of platelet transfusion, but the failure rate of platelet transfusion in patients complicated with in- fection, splenomegaly and disseminated intravascular coagulation was significantly higher than that in patients without complications （P 〈 0. 05 ）. Conclusion Platelet transfusion in the treatment of patients with hemato- logic diseases is of good curative effect. To further improve the effectiveness of the treatment, the factors such as infection, splenomegaly and disseminated.