半乳糖凝集素-3与心力衰竭相关性

Correlation of galectin-3 and heart failure

心力衰竭（heart failure，HF）的病理生理基础是心室重构，而心室重构的基础是炎症和纤维化。近年研究发现，半乳糖凝集素－3在心脏调节机制中起重要作用，它的表达水平反映了心力衰竭的严重程度和分层，并可作为预测心力衰竭预后的生物学指标，但它在治疗心力衰竭方面的研究尚未成熟。本文综述了半乳糖凝集素－3与心力衰竭的相关研究，为临床医生提供了新的治疗思路。

The pathophysiological basis of heart failure （ HF） is ventricular remodeling on the basis of inflammation and fibrosis .In recent years , evidence shows that galectin-3 plays an important role in the mechanism of cardiac regulation and has been recognized as a biological predictor for HF prognosis because its expression level reflects the severity and hierarchical of HF .However , its effect in the treatment of HF remains unclear .This article reviewed the studies on the correlation of galectin-3 and HF in order to provide new therapy ideas for clinicians .