摘要
【目的】探讨非ST段抬高型急性冠脉综合征（NSTE-ACS）患者高敏C反应蛋白（hs-CRP）水平与冠状动脉狭窄程度、肌钙蛋白T（cTnT）的相关性。【方法】根据患者入院时的血清hs-CRP水平将225例确诊为NSTE-ACS的患者分为正常组（≤3mg／L，n=105）和升高组（〉3mg／L， n=120）。采用微粒子增强透射免疫分析法测定hs-CRP、电化学发光法测定cTnT，同时作冠状动脉造影定量计算冠状动脉病变积分（CAS），评价冠状动脉狭窄程度。【结果】升高组与正常组CAS评分差异无统计学意义[（49．14±31．80）分vs（50．81±34．64）分，t=0.439，P〉0．05）]；升高组血清cTnT显著高于正常组，差异具有统计学意义[（3．78±1．42）mmol／L vs （1．89±1．59）mmol／L，t=2．148，P〈0．05）]；hs-CRP水平与cTnT水平呈显著正相关（r=0．478，P〈0．05），与CAs水平呈负相关，但差异无统计学意义（r=0．169，P〉0．05）。【结论】血清hs-CRP水平对NSTE-ACS的诊断具有重要的临床价值，但与冠状动脉狭窄病变程度无明显相关性。
[Objective]To study the relations among the high sensitive C-reactive protein （hs-CRP）, the coronary ar- tery stenosis, and Troponin T（cThT） in patients with Non-ST-elevation acute coronary syndromes （NSTE-ACS）. [Methods]According to hs-CRP level, 225 patients diagnosed as NSTE-ACS in our hospital were divided into two groups （Group A with normal level hs-CRP≤3 mg/L, n =105 and Group Bwith high level hs-CRP 〉3 rag/L, n =120）. Data of coronary stenosis score （CAS） and quantity of Troponin T （cTnT） in both groups were compared and analyzed. IRe- sults]There was no difference in coronary stenosis score between the two groups [（49.14±31.80） vs （50.81± 34.64）, t =0.439, P〉0.05]. However, the quantityx）f Troponin T in Group B was higher than that of in Group A[ （3.78±1.42 ）mmol/L vs （1.89±1.59）mmol/L, t =2.148, P〈0.05]. A positive relation was found between hs-CRP count and the quantity of Troponin T（r=0.478,P〈0.05）, however, a negative relation was showed between hs-CRP count and CAS score （r = 0.169, P〉0.05）. [Conclusion]hs-CRP can be used in predicting the prognosis of patients with NSTE-ACS. As an important indicator, it also has important clinical significance in terms of treatment, however, hs-CRP shows no rela- tionship with the degree of coronary stenosis score in NSTE-ACS patients.
出处
《医学临床研究》
CAS
2016年第7期1351-1352,1355,共3页
Journal of Clinical Research
