补体C1q在系统性红斑狼疮及狼疮肾炎诊断监测应用研究

Study on the Application of C1q in the Diagnosis and Monitoring of Systemic Lupus Erythematosus and Lupus Nephritis

目的分析补体C1q在系统性红斑狼疮及狼疮肾炎诊断监测应用价值。方法将20例系统性红斑狼疮和狼疮肾炎患者设置为观察组,将200例排除狼疮性肾脏损害的自身免疫疾病患者和原发性继发性肾脏群为疾病对照组,正常健康体检者200例为对照组,比较其血清补体、胱抑素C以及C1q和抗da-DNA。结果观察组患者的血清C1q水平低于疾病对照组和对照组,活动期患者血清C1q低于稳定期患者血清C1q。结论本研究证明C1q水平与SLE尤其SLE患者的肾脏损害之间存在相关性。活动期检测水平下降,缓解期水平高于活动期。可作为评价LN患者治疗效果及病情活动性变化的指标,作为监测手段真正应用于临床。为LN患者早期明确诊断以及提早用药干预提供了依据。

Objective To analyze the value of Clq in the diagnosis and monitoring of systemic lupus erythematosus and lupus nephritis. Methods Will be 211 casts set system lupus erythematosus and lupus nephritis patients as the observation group, the 20 cases excluded lupus rena｜ damage in patients with autoimmune diseases and primary, secondary, renal group for disease control group, normal healthy volunteers 20 cases as control group, compare the serum complement, cystatin C and Clq and anti da-DNA. Results The serum level of Clq in the observation group was significantly lower than that in the control group and the control group. The serum C Iq was sigalificantly lower than that of the stable stage in the active stage of the disease control group and the control group, Clq. Conclusion Serum C1q and systemic lupus erythematosus patients and lupus nephritis patients have a greater degree