大肠肿瘤高危人群的随访研究

Follow-up Study in the High-risk Group of Colorectal Tumor

目的：通过大肠肿瘤高危人群的随访研究,为制定大肠癌的筛查指南提供客观证据。方法：分别统计583例大肠肿瘤高危人群随访5年后大肠肿瘤的发病率,计算相对危险度（RR值）及相对危险度的95%可信区间（RR的95%CI）。结果：583例大肠肿瘤高危人群肠镜随访5年后,结果显示：糖尿病病史、大肠腺瘤性息肉病史与大肠腺瘤的发病相关,RR值分别为1.645、1.578及RR的95%CI分别为1.019～2.655、1.228～2.029;胆囊疾病病史、糖尿病病史与大肠癌的发病相关,RR值分别为5.951、4.419及RR的95%CI分别为1.017～34.829、1.076～18.146。结论：队列研究结果显示：糖尿病病史、既往有大肠腺瘤性息肉病史为大肠腺瘤发病的危险因素,胆囊疾病病史及糖尿病病史为大肠癌发病的危险因素。

Objective：With a follow-up study in the high-risk group of colorectal tumor,to provide objective evidence in the development of colorectal cancer screening guidelines.Methods：Statistics the incidence of colorectal tumor in the583high-risk group of colorectal tumor patients after 5-year follow-up study,relative risk（RR values）and confidence interval of 95 relative risk（RR of 95%CI）.Results：After a 5years follow-up study in the 583high-risk group of colorectal tumor,show that the incidence of colorectal tumor was related to diabetes,previous history of colorectal adenomatous polyps,with the relative risk（RR）：1.645,1.578 and the RR of 95%CI：1.019～2.655,1.228～2.029;the incidence of colorectal cancer was related to gallbladder disease,diabetes,with the relative risk RR：5.951,4.419 and the RR of 95%CI：1.017～34.829,1.076～18.146.Conclusion：Retrospective cohort study showed that diabetes,previous history of colorectal adenomatous polyps are the risk factors for colorectal adenoma,and chronic cholecystitis/cholelithiasis/cholecystectomy,diabetes are the risk factors for colorectal cancer.