摘要
目的综合评价奥卡西平治疗癫痫部分性发作的安全性和有效性。方法在Pub Med、EMBASE、Cochrane、万方、CNKI、维普数据库上检索奥卡西平与其他抗癫痫药单药治疗癫痫部分性发作的随机对照试验,采用文献筛选软件Endnote进行文献查重及筛选,采用Meta分析专用软件Rev Man 5.3进行系统评价。结果初检2 716篇文献,最终纳入15篇文献,共2 040例患者,分析结果提示奥卡西平治疗癫痫部分性发作的控制率为66.11%,其他抗癫痫药物的控制率为62.00%,奥卡西平和其他抗癫痫药在癫痫部分性发作控制率上差异无统计学意义[RR=1.17,95%可信区间(0.95,1.45)]。奥卡西平与其他抗癫痫药物在癫痫部分性发作治疗中的不良反应发生率上差异无统计学意义[RR=0.67,95%可信区间(0.40,1.12)]。结论奥卡西平治疗癫痫部分性发作有效,但长疗程的安全性有待进一步研究。
Objective To evaluate the effect and safety of oxcarbazepine for the partial-onset epilepsy. Methods Searching for database about randomised controlled trials（ RCT） of oxcarbazepine and other antiepileptic drug monotherapy treat partial seizures in Pub Med,EMBASE,Cochrane,Wanfang database,CNKI,VIP database,using literature screening software Endnote check literature and screening,using Meta-analysis of the special software Rev Man 5. 3 system evaluation.Results Total 2 716 reference studies were screened,in which 15 trials were chosen including 2 040 patients in all. The analysis showed that oxcarbazepine in the treatment of partial onset seizure control rate was 66. 11%,other antiepileptic drugs control rate was 62%,oxcarbazepine and other antiepileptic drugs in partial seizure control rate had no significant difference[RR = 1. 17,95% CI（ 0. 95,1. 45） ]. Oxcarbazepine and other antiepileptic drugs in partial seizures in the adverse reactions in the treatment there was no significant difference[RR = 0. 67,95% CI（ 0. 40,1. 12） ]. Conclusion For the existing evidence,the control rate and the incidence of adverse reactions of oxcarbazepine in the treatment of partial epilepsy is safety and effective. However,the long course of security needs further research.
出处
《创伤与急危重病医学》
2016年第4期245-252,共8页
Trauma and Critical Care Medicine
