阿尔茨海默病患者血浆脂联素水平及临床意义

Levels of Serum Adiponectin and Its Clinical Significance in Patients with Alzheimer's Disease

目的:探讨阿尔茨海默病(AD)患者血浆脂联素(APN)水平变化及其与认知功能的关系。方法:收集AD患者20例(AD组)、健康老年人20例(对照组),检测并比较2组血浆APN含量,分析APN含量与MMSE、性别和年龄的关系。结果:对照组和AD组的血浆APN含量分别为(7.08±2.61)μg/m L、(5.58±1.83)μg/m L,AD组低于对照组(P<0.05)。血浆APN含量与MMSE评分呈显著正相关(r=0.531,P<0.01)。男性、女性血浆APN含量差异无统计学意义(P>0.05)。血浆APN含量与年龄无明显相关性(r=-0.277,P>0.05)。结论:AD患者血浆APN水平明显降低,血浆APN水平改变与其认知功能减退存在一定的相关性。

Objective： To investigate the relationship between changes of serum adiponectin （APN） level and cognitive fimction in patients with Alzheimer＇s disease （AD）. Methods： The levels of serum adiponectin in 20 AD patients （AD group） and 20 healthy elderly people （control group） were examined and compared. The rela- tionships among serum adiponectin, MMSE scores, gender and age were analyzed. Results： The serum APN in the control group and AD group were （7.08±2.61）μg/mL, （5.58±.83）μg/mL respectively, and the level of APN in the AD group was significantly lower than that in the control group （P〈0.05）. The levels of serum APN had sig- nificantly positive correlation with MMSE scores （r=0.531, P〈0.01）. There was no significant difference in se- rum adiponectin between male and female （P〉0.05）. The levels of serum had no significant correlation with age （r=- 0.277, P〉0.05）. Conclusion： The level of serum APN was significantly decreased in AD patients. There is obvious correlation between the changes of serum APN and cognitive impairment in these patients.