从现代化学成分研究探讨浙贝母芯芽去留的必要性

Discussion on the Necessity of Preserving the Bud of Zhebeimu(Fritillariae thunbergii bulbus) based on Modern Chemical Analysis

目的:探讨浙贝母加工是否可以保留芯芽。方法:通过查阅文献,总结了浙贝母药用沿革和加工历史,并采用HPLC测定比较了浙贝母鳞叶与芯芽中贝母素甲、贝母素乙的含量。结果:临床上浙贝母鳞叶和芯芽都有入药历史,现代化的加工干燥技术可对不去芯芽的浙贝母实现优质生产;浙贝母芯芽中生物碱的含量高于鳞叶。结论:从临床用药,药效物质生物碱含量,炮制加工新方法和资源节约综合考虑,浙贝母加工应保留芯芽。

Objective： To investigate whether to retain the bud processing Fritillariae thunbergii bulbus.Methods： Through consulting literature, we summarized the medicinal history and processing history of Fritillariae thunbergii bulbus, determined and compared the content of peimine, peiminine in Fritillary scale leaves and core bud of Fritillary with HPLC. Results： The Fritillaria thunbergii leaf and bud core both have been used as medicine in history, modern processing and drying technology can realize high quality production of Fritillaria thunbergii with core of bud, Fritillaria thunbergii core of bud has a higher alkaloid content than Fritillary scale leaves. Conclusion： Comprehensive consideration of clinical medicine, alkaloid content of active substance, new method of processing and resource saving, Fritillaria thunbergii processing should retain the core bud.