血必净对合并感染肺癌患者肺功能及炎症因子的影响

The Influence of XueBiJing on Lung Function and Inflammatory Factors of Lung Cancer Patients Complicated with Infection

目的:探讨血必净对合并感染肺癌患者肺功能及其炎症因子的影响。方法:将92例患者随机分为对照组、观察组各46例。2组均给予辅助通气、解痉、抗感染和抗凝等常规治疗,观察组同时静脉滴注血必净注射液,2次/d。2组均连续治疗2周。分别于治疗前和治疗14天后测定动脉血氧分压(Pa O_2)、动脉血二氧化碳分压(Pa CO_2)和外周血炎性因子水平。结果:Pa O_2、Pa CO_2治疗后2组均明显改善,观察组改善更明显差异有统计学意义(P<0.05)。肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)均有所降低,观察组降低更明显差异有统计学意义(P<0.05)。结论:血必净联合抗生素可改善感染合并肺癌患者的肺功能血气指标,并可降低TNF-α、IL-6、IL-8以及高敏C反应蛋白等炎症因子水平。

Objective： To explore the influence of Xue Bi Jing on lung function and inflammatory factors of lung cancer patients complicated with infection. Methods： All 92 patients were randomly allocated to the control group and the observation group, 46 cases each group. Both groups accepted routine treatment of assisted ventilation, relieving spasm, anti-infection, anti-coagulation and others, the observation group received intravenous dripping of Xue Bi Jing injection, twice per day. Both groups were treated for two weeks consecutively. The levels of Pa O2, Pa CO2 and inflammatory factors in peripheral blood were detected before treating and in 14 days after treating respectively. Results： The levels of Pa O2 and Pa CO2 improved notably in both groups after treating（P〈0.05）, the improvement of the observation group was more evident（P〈0.05）. The levels of TNF-α, IL-6 and IL-8 lowered（P〈0.05）, the decrease of the observation group was more evident（P〈0.05）. Conclusion： Xue Bi Jing and antibiotics could improve blood gas indexes of lung function, decrease the levels of inflammatory factors including TNF-α, IL-6, IL-8 and CRP of lung cancer patients complicated with infection.