老年乳腺癌组织中激素受体与人表皮生长因子受体-2及特异性核基质结合蛋白表达的相关性

Correlation of hormone receptor expression with human epidermal growth factor receptor 22 and special AT rich sequence binding protein in elderly breast cancer

目的探讨乳腺癌组织中激素受体（HR）与人表皮生长因子受体-2（Her-2）、特异性核基质结合蛋白（SATB1）的表达与乳腺癌临床病理特征问的关系。方法选取86例老年乳腺癌组织切除标本为观察组，42例远癌区距肿瘤切缘〉5cm的癌旁组织为对照组，检测其孕激素受体（PR）、雌激素受体（ER）、Her-2及SATBl蛋白的表达，对其HR（包括PR和ER）的表达与Her-2、SATBl及乳腺癌患者临床病理参数间的关系进行比较分析。结果观察组中86例乳腺癌组织，ER、PR、HR阳性率分别为51．16％、47．67％、59．30％，ER和PR的阳性率基本一致，差异无统计学意义（P〉0．05）；乳腺癌患者ER和PR表达与在肿瘤大小、组织学类型、TNM分期和有无淋巴结转移等临床病理特征无明显相关（P〉0．05）；在年龄分级和肿瘤分级方面，差异有统计学意义（P〈0．05）；乳腺癌组织中HR的表达与Her-2（r=-0．388，P〈0．01）、SATB1（r=-2．502，P〈0．05）及Her-2／SATBl（r=-0．435，P〈0．01）双阳性表达均呈负相关。结论HR与Her．2、SATBl在乳腺癌组织中的表达呈负相关，乳腺癌患者HR阳性者相对预后较好，可能有相互联系的信号通路存在于三者问。

Objective TO investigatethe reiationship or hormone receptor （HR） with human epi- dermal growth factor receptor 2 （ Her - 2）, the special AT rich sequence binding protein （ SATB1 ） expres- sion and clinicopathological features of breast cancer. Methods Eighty - six cases of breast cancer tissue specimens served as the observation group, and 42 cases of paracancerous tissues far away from the tumor margin 〉 5 cm as the control group. The progesterone receptor （PR）, estrogen receptor （ER）, expres- sion of Her-2 and SATB1 proteins were detected. The relationship of HR （including PR and ER） with the expression of Her- 2 and SATB1 proteins and clinicopathological parameters of breast cancer patients was analyzed. Results In the observation group, ER, PR and HR positive rate was 51.16%, 47.67% , and 59. 30% respectively. There was no significant difference in the positive rate of ER and PR （ P 〉 0. 05）. The ER and PR expression in breast cancer patients was not obviously correlated with tumor size, histological type, TNM stage and lymph node metastasis （P 〉 O. 05 ）, but with age and tumor grade （ P 〈 0. 05）. The HR expression in breast cancer tissues was negatively correlated with Her - 2 （ r = - 0. 388, P 〈 0. 01 ）, SATB1 （ r = - 2. 502 ,P 〈 0. 05 ） and Her - 2 / SATB1 （ r = - 0. 435 ,P 〈 0. 01 ）. Conclusion HR is negatively coreelated with Her- 2 and SATB1 expression in breast cancer tissues. The prognosis of breast cancer patients positive for HR was relatively good. Theremay be inter - related signaling pathway existing among the three parts.