血清骨桥蛋白在慢性萎缩性胃炎和胃癌患者中的表达及临床意义

Exploration of the indication of serum OPN level for chronic atrophy gastritis and gastric cancer

目的探讨血清骨桥蛋白（OPN）在慢性萎缩性胃炎、胃癌患者中的表达及临床意义。方法 收集2011年至2014年期间在本院就诊的慢性萎缩性胃炎（CAG）患者，胃癌（GC）患者各30例，并选取30例健康体检者作为对照组，所有对象均行13C呼气试验测定幽门螺杆菌（HP）感染情况，采用ELISA方法测定血清OPN水平。结果 对照组、CAG组、GC组的血清OPN浓度分别为（38.24±10.12）ng/ml、（50.23±17.24）ng/ml、（99.17±11.12）ng/ml，三组差异有统计学意义，CAG、GC组的OPN阳性率均高于正常组（P〈0.05）。相关性分析提示，血清OPN浓度与年龄、HP感染率呈正相关。结论 血清OPN浓度在慢性萎缩性胃炎、胃癌患者中明显升高，血清OPN可作为萎缩性胃炎、胃癌的预测因子。

Objective To investigate the relationship between serum osteoponin （OPN） and gastric cancer （GC） and its precancerous disease, chronic atrophic gastritis （CAG）, to explore the diagnostic efficacy of serum OPN level for GC and CAG. Methods Thirty CAG patients and 30 GC patients who cured in our hospital were enrolled, and 30 normal people were chosen as the control. All patients and the controls were detected by enzyme-linked immunosorbent assay （ELISA）. Helicobacter pylor status was judged with 13C urea breath test. Results Serum OPN levels increased from the control [ （38.24 ± 10. 12） ng/ml] to CAG [ （50. 23 ± 17.24）ng/ml] to GC [ （99. 17 ± 11.12）ng/ml], along with increasing severity of gastric disease. Serum OPN level was positively correlated with age and helicobacter pylor （HP） infection status. Conclusions Serum OPN levels were significantly higher in patient with CAG and GC, and it might be a useful marker for the diagnosis of CAG and GC.