肺癌高危人群中低剂量CT联合血清肿瘤标志物对肺癌早期诊断的可行性分析

The feasibility of low dose CT combined with serum tumor markers in the early diagnosis of lung cancer at high risk of lung cancer

目的探讨肺癌高危人群中低剂量CT(LDCT)联合血清肿瘤标志物对肺癌早期诊断的可行性。方法筛选1020例来我院进行体检的肺癌高危人群,按照随机数字法分为两组:LDCT+血清肿瘤标志物组420例与CXR组600例。比较两组检查结果。结果(1)本次研究进行CXR检查的600例患者中,12例(2.0%)存在多个非钙化的结节情况;给予相关检查后,2例确诊为该种癌症,所占比重为0.33%;本组420例受检者之中,56例(占13.33%)经LDCT检查发现存在不同个数的非钙化结节,显著高于CXR组(P<0.01);(2)对比3组血清标志物水平,CEA水平在3组之间存在显著性差异(P<0.01)。结论 LDCT联合血清肿瘤标志物对肺癌早期诊断可行性较高,且临床价值高。

Objective To investigate the feasibility of low dose CT（LDCT） combined with serum tumor markers in lung cancer at high risk for early diagnosis of lung cancer.Methods A total of 1020 patients with lung cancer in our hospital were divided into 2 groups according to the random number method： 420 cases of LDCT＋ serum tumor marker group and 600 cases of CXR group.Comparison of two groups of inspection results.Results（1） In the group that 600 cases examined by CXR,12 cases（2%） were found to have different numbers of non calcified nodules.The CXR,final diagnosed with lung cancer in 2 cases（0.33%）; in the group with 420 subjects,56 patients（13.33%） found that there is a different number of non calcified nodules by LDCT,significantly higher than that of CXR group（P0.01）;（2） LDCT ＋ serum tumor signs in groups,diagnosed lung cancer group（n=5）,screening positive group（n=56） and screening negative group（n=359） three groups of serum tumor markers compared to CEA levels between the three groups there was significant difference（P0.01）.Conclusion LDCT combined with serum tumor markers in lung cancer high-risk population is feasible in the early diagnosis of lung cancer,and the clinical value is high.