HE4、CA125、CA153联合CA199检测在妇科肿瘤诊疗中的应用

The application of HE4, CA125, CA153 and CA199 detection in the diagnosis and treatment of gynecological tumors

目的探讨人附睾蛋白(HE4)、癌症抗原125(CA125)、糖类抗原(CA153)、糖类抗原(CA199)联合检测在妇科肿瘤中诊断效果。方法选取2013年3月至2015年11月我院妇科收治妇科肿瘤患者108例为研究组,根据患者病理检查结果分为恶性组(48例)、良性组(60例),选取同期我院体检中心体检健康女性50名作为对照组,检测并比较各组HE4、CA125、CA153、CA199及联合检测阳性率。结果研究组HE4、CA125和联合检测阳性率高于对照组(P<0.05)。良性组、恶性组中HE4、CA125及联合检测阳性率高于对照组,恶性组CA153阳性率高于对照组,恶性组联合检测阳性率高于良性组,组间各值比较有统计学意义(P<0.05)。结论 HE4、CA125在妇科肿瘤中诊断有重要价值,联合CA153、CA199检测可提高临床诊断率,特别可提高恶性肿瘤诊断率。

Objective To investigate the effect of combination detection of human epididymal protein 4 （ HE4）, cancer antigen 125 （ CA125 ）, carbohydrate antigen （ CA153 ） and carbohydrate antigen （ CA199 ） in the differential diagnosis of gynecological tumors. Methods 108 cases of gynecologic cancer patients, admitted to department of gynecology of our hospital between March 2013 and November 2015, were selected as the study group in, according to the pathological findings they were divided into malignant group （48 eases） and benign group （60 cases） , 50 healthy women from medical center examination department in our hospital were chose as a control group. The concentration of HE4, CA125, CA153 and CA199 were detected and the positive rate of single detection and combined detection were compared. Results Positive rate of HE4, CA125 and joint detection in study group was higher than that in control group （ P 〈 0. 05 ）. Positive rate of HE4, CA125 and joint detection in benign and malignant group was higher than control group. Positive rate of CA153 in malignant group was higher than that in control group, and positive rate of combined detection of malignant group was higher than benign group, the differences between the two groups were statistically significant （ P 〈 0.05）. Conclusions HFA and CA125 has important value in the diagnosis of gynecological tumors, HE4 and CA125 combined with detection of CA153 and CA199 can improve the diagnosis rate, especially improves diagnosis rate of therioma.