摘要
自噬是细胞"吃"自身的一种分解代谢过程,细胞通过降解更新细胞内异常的蛋白质、糖原、受损细胞器等累积物,以此应对细胞内外环境变化的压力,维持细胞内稳态,保证细胞生命活动的正常进行。在眼部,从眼睛前部的角膜细胞,到眼睛后部的视网膜上皮细胞,自噬均参与其结构的保持及功能的调节。自噬对视网膜主要有神经保护的作用,自噬在视网膜色素上皮细胞中的缺陷可能促进年龄相关性黄斑病变的发生,而自噬在视网膜神经节细胞中的异常可能加速青光眼的发生。
Autophagy is a catabolic process, by which cells can eat themselves, degrade abnormal protein, glycogen and other damaged organelles to respond to the intraccllular and cxtracellular pressure. Autophagy is important to maintain eel1 stability and ensure the normal activity of eells. Here we will mainly discuss the neuroprotective effect of autophagy on the normal retina and retinal diseases.The deficiency of autophagy activity in retinal pigment epithelial cells may result in age-related maeular degeneration. Any problem of autophagy in retinal ganglion cells may increase the risk of occurrence of glaucoma.
出处
《解剖科学进展》
2016年第4期429-431,共3页
Progress of Anatomical Sciences
基金
辽宁省博士科研启动基金(20131141)
辽宁省自然科学基金(20132105)
教育部高校博士学科点基金(20132104120015)
