microRNAs在视网膜母细胞瘤的研究进展

Progress of micro RNAs in retinoblastoma

视网膜母细胞瘤是婴幼儿最常见的眼内恶性肿瘤,预后较差。MicroRNA(miRNA)是一类在生物体内广泛表达的非编码小分子RNA,不仅参与调节生物体的生长发育,还与包括肿瘤在内的多种疾病的发生发展密切相关。多种miRNA参与视网膜母细胞瘤的病理进程,或者作为癌基因抑制肿瘤细胞凋亡、促进肿瘤细胞增殖、侵袭和转移,或者作为抑癌基因促进肿瘤细胞凋亡,或者与临床病理特征及不良预后密切相关。

Retinoblastoma （RB） is the most common intraocular malignancy of children with extremely poor prognosis. MicroRNA（miRNA） is a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. MiRNAs have been found to perform an essential role not only in various biologic processes, but also in abnormal state including the occurrence and development of neoplasm. Many miRNAs were involved in the pathological process of RB, such as inhibiting apoptosis and promoting proliferation,invasion and metastasis of RB ceils acting as oncogene, promoting apoptosis of RB cells acting as a tumor suppressor gene, or closely relating to the clinical pathological features and prognosis.