血黏度、血脂联合检测对缺血性结肠炎预后的评估价值

Value of combined detection of blood viscosity and blood lipid in evaluating the prognosis of ischemic colitis

目的研究血黏度、血脂联合检测对缺血性结肠炎预后的评估价值。方法选取2010年5月至2015年5月我院40例缺血性结肠炎患者作为观察组,再根据预后结果分为三组(优良组、尚可组、较差组),选择同一时期我院体检健康者40例为对照组,检测四组研究对象高切变率下全血黏度、低切变率下全血黏度、总胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及载脂蛋白A1(Apo-A1)水平。分析上述指标与患者预后关系。结果观察组高切变率下全血黏度、低切变率下全血黏度、CHOL及LDL-C分别为(7.03±1.24)m Pa/s、(12.28±2.67)m Pa/s、(6.49±0.97)mmol/L及(2.71±0.63)mmol/L,显著高于对照组,差异有统计学意义(P<0.05)。观察组高切变率下全血黏度、低切变率下全血黏度、CHOL及LDL-C与预后具有显著负相关性,HDL-C和Apo-A1水平与预后具有显著正相关性,差异有统计学意义(P<0.05)。结论血黏度联合血脂检测可作为诊断缺血性结肠炎的参考指标,联合检测对判断预后和指导临床治疗具有重要参考价值。

Objective To study the value of combined detection of blood viscosity and blood lipid in evaluating the prognosis of ischemic colitis. Methods 40 patients with ischemic colitis who were admitted in our hospital between May 2010 and May 2015 were selected as the observation group. According to the prognosis, they were divided into three groups（excellent group, passable group, poor group）. 40 healthy persons who underwent physical examination in the same period were included in the control group. The levels ofhigh shear whole blood viscosity, low shear whole blood viscosity, total cholesterol（CHOL）, high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） and apolipoprotein A1（Apo-A1） were detected. The relationship between the above indexes and the prognosis of patients was analyzed. Results The levels of high shear whole blood viscosity, low shear whole blood viscosity, CHOL and LDL-C in the observation group [（7.03 ±1.24）m Pa / s,（12.28±2.67）m Pa / s,（6.49±0.97）mmol / L,（2.71±0.63） mmol / L] were significantly higher than those in the control group（P〈0.05）.The levels of high shear whole blood viscosity, low shear whole blood viscosity, CHOL and LDL-C were significantly negatively correlated with prognosis while HDL-C and Apo-A1 levels were significantly positively correlated with prognosis（P〈0.05）. Conclusion Combined detection of blood viscosity and blood lipid can be used as a reference index for the diagnosis of ischemic colitis. The combined detection is of important reference value in judging prognosis and guiding clinical treatment.