注射用丹参多酚酸盐联合巴曲酶治疗进展性脑卒中的疗效观察

Observation of curative effect by salvianolate for injection combined with batroxobin in the treatment of progressive stroke

目的研究注射用丹参多酚酸盐联合巴曲酶治疗进展性脑卒中的临床效果。方法 40例进展性脑卒中患者,随机分为对照组与观察组,各20例。对照组给予常规吸氧、调脂、脱水、清除自由基以及营养脑神经等治疗,观察组同时采用注射用丹参多酚酸盐与巴曲酶联合治疗。比较两组的治疗效果。结果观察组治疗总有效率(80.0%)高于对照组(50.0%)(P<0.05);治疗后观察组美国国立卫生院神经功能缺损评分(NIHSS)及日常生活能力(ADL)评分优于对照组(P<0.05)。结论在进展性脑卒中治疗用药方案中,注射用丹参多酚酸盐联合巴曲酶疗效确切,可有效改善患者神经功能缺损症状,改善其生活质量,值得临床加以推广应用。

Objective To research clinical effect by salvianolate for injection combined with batroxobin in the treatment of progressive stroke. Methods A total of 40 progressive stroke patients were randomly divided into control group and observation group, with 20 cases in each group. The control group received conventional therapy by oxygen inhalation, lipid regulation, dehydration, free radical scavenging and cranial nerve nourishing, and the observation group received additional salvianolate for injection combined with batroxobin. Curative effects of the two groups were compared. Results The observation group had higher total effective rate（80.0%） than the control group（50.0%）（P〈0.05）. After treatment the observation group had higher national institutes of health stroke scale（NIHSS） and activities of daily living（ADL） scores than the control group（P〈0.05）. Conclusion Combination of salvianolate for injection and batroxobin in treating progressive stroke provides precisely curative effect. This method can improve neurologic impairment and quality of life in patients, and it is worth clinical promotion and application.