丁苯酞对缺血性脑卒中疗效的分析

Analysis of curative effect by butylphthalide for ischemic stroke

目的探讨丁苯酞治疗缺血性脑卒中的临床疗效。方法 260例缺血性脑卒中患者,随机分为对照组和实验组,各130例。对照组采用传统药物治疗,实验组采用丁苯酞治疗。比较两组治疗效果。结果实验组63例显著好转,62例好转,5例无好转,总有效率为96.15%;对照组34例显著好转,79例好转,17例无好转,总有效率为86.92%;实验组总有效率优于对照组(P<0.05)。实验组治疗第1、15、30天的NIHSS评分分别为(17.25±3.36)、(9.65±3.28)、(6.28±1.21)分,对照组分别为(16.98±3.21)、(13.12±3.35)、(8.98±1.85)分。两组治疗第1天NIHSS评分比较差异无统计学意义(P>0.05),实验组治疗第15、30天NIHSS评分优于对照组(P<0.01)。结论丁苯酞对缺血性脑卒中有较好疗效,可促进缺血性脑卒中的恢复。

Objective To investigate clinical effect by butylphthalide in the treatment of ischemic stroke. Methods A total of 260 patients with ischemic stroke were randomly divided into control group and experimental group, with 130 cases in each group. The control group received traditional drug therapy, and the experimental group received butylphthalide. Curative effects of the two groups were compared. Results The experimental group had 63 cases with significant improvement, 62 cases with improvement and 5 cases without improvement, and its total effective rate was 96.15%. There were 34 cases with significant improvement, 79 cases with improvement and 17 cases without improvement in the control group, with total effective rate as 86.92%. The experimental group had better total effective rate than the control group（P〈0.05）. NIHSS scores in 1, 15, 30 d of treatment were respectively（17.25±3.36）,（9.65±3.28） and（6.28±1.21） points in the experimental group, and they were respectively（16.98±3.21）,（13.12±3.35） and（8.98±1.85） points in the control group. There was no statistically significant difference of NIHSS score in 1 d of treatment between the two groups（P〈0.05）. The experimental group had better NIHSS scores in 15 and 30 d of treatment than the control group（P〈0.01）. Conclusion Butylphthalide shows precisely curative effect for ischemic stroke, and it can accelerate rehabilitation of ischemic stroke.