丁二磺酸腺苷蛋氨酸治疗急性黄疸型肝炎的疗效观察

Observation of curative effect by ademetionine 1, 4-butanedisulfonate in the treatment of acute icteric hepatiti

目的观察丁二磺酸腺苷蛋氨酸治疗急性黄疸型肝炎疗效。方法 42例急性黄疸型肝炎患者为研究对象,随机分为对照组(21例,采用常规复方甘草酸苷、还原型谷胱甘肽等保肝治疗)及治疗组(21例,常规保肝药物联合丁二磺酸腺苷蛋氨酸治疗),观察两组疗效。结果治疗后,治疗组总有效率明显高于对照组(P<0.05),总胆红素水平明显优于对照组(P<0.05);两组均未见药物相关不良反应。结论丁二磺酸腺苷蛋氨酸可作为临床治疗急性黄疸型肝炎的首选药物,其退黄效果明显,疗效显著,促进患者生存质量的改善,值得应用。

Objective To observe curative effect by ademetionine 1, 4-butanedisulfonate in the treatment of acute icteric hepatitis. Methods A total of 42 acute icteric hepatitis patients as study subjects were randomly divided into control group（21 cases, received compound glycyrrhizin and reduced glutathione for liver protection） and treatment group（21 cases, received conventional liver-protective agent combined with ademetionine 1, 4-butanedisulfonate）. Curative effects of both groups were compared. Results After treatment, the treatment group had obviously higher total effective rate（P〈0.05） and better total bilirubin level than the control group（P〈0.05）. Both groups had no drug-related adverse reactions. Conclusion Ademetionine 1, 4-butanedisulfonate can be applied as the preferred drug in treating acute icteric hepatitis, as it provides precisely curative effect and improves quality of life. This method is worth applying.