摘要
恶性肿瘤发生发展过程中会产生突变蛋白,可作为抗原而被免疫系统识别.然而机体往往难以产生有效控制肿瘤的免疫反应,即形成所谓肿瘤的免疫逃逸状态.B7-H1是表达在免疫和肿瘤细胞中的B7家族分子,被发现是维持免疫逃逸的重要机制.B7-H1作为共刺激分子,能够在T细胞免疫起始和效应阶段下调抗肿瘤免疫反应;又参与调节肿瘤细胞自身增殖、凋亡和侵袭等生物学行为.阻断B7-H1,在临床前肿瘤模型和临床试验中显现出巨大的抗肿瘤效应.B7-H1阻断可能为胃肠道肿瘤提供新的治疗途径.本文就B7-H1参与肿瘤免疫逃逸的机制及在胃肠道肿瘤中的研究进展作一综述.
Immune evasion is a hallmark of cancer.Althoughcancer cells have been shown to be able to be recognized by T cells,host immune system fails to develop effective antitumor activity and tumor control.B7-H1,an immune inhibitory molecule,plays an important role in the immune evasion process.B7-H1 inhibits T cell immunity during immune priming and effector phases and is also implicated in intrinsic proliferation,apoptosis and migration of tumor cells.Targeting B7-H1 using blockade antibodies has generated immense antitumor activity in preclinical tumor models.Durable response for a variety of tumor types was also documented in clinical trials.Thus,B7-H1 targeted immune therapy offers a new line of tumor treatment.Gastrointestinal cancer is one of the leading causes of tumor morbidity.However,traditional therapy has not been able to effectively improve survival.This review will focus on the role of B7-H1 in immune evasion and the latest progression of the B7-H1 blockade immune therapy in gastrointestinal cancer.
出处
《世界华人消化杂志》
CAS
2016年第20期3135-3141,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81572413~~
