脂蛋白a与颈动脉易损斑块的相关性研究

Study on the Relationship between Lipoprotein(a) and Carotid Vulnerable Plaques

目的探讨脂蛋白a[Lp（a）]与颈动脉易损斑块的相关性。方法选取2014年12月~2015年6月本院收治的124例颈动脉斑块患者为研究对象,根据颈动脉超声结果将颈动脉斑块分为软斑块、纤维斑块及钙化斑块。采用免疫比浊法测定患者的血清Lp（a）水平,以Lp（a）中位数将患者分为Lp（a）高水平组及Lp（a）低水平组,比较两组患者间不同斑块的发生率。结果与Lp（a）低水平组相比,高水平组软斑块发生率高、纤维斑块发生率低（P〈0.05）。两组间钙化斑块的发生率无显著差异（P〉0.05）。结论高水平Lp（a）可能与易损斑块发生有关,降低Lp（a）水平有助于稳定斑块。

Objective To examine the association between Lipoprotein（a） [Lp（a）] levels and carotid vulnerable plaques. Methods A total of 124 carotid plaques patients who were treated in our hospital between June 2015 and January 2016 were enrolled in this study. The carotid plaques were classified into three types according to respective features： soft plaque, fibrous plaque and calcified plaque. Serum Lp（a） levels were measured by immunoturbidimetric assay. According to the median, Lp（a） was divided into high level group（Group A） and low level group（Group B）, then the incidence of carotid plaque between the two groups was compared. Results The prevalence of soft plaque was significantly higher, fibrous plaque was significantly lower in Group A than Group B（P〈0.05）. There was no significant difference in the incidence of calcified plaques between the two groups（P〈0.05）. Conclusion These results suggested that high-level Lp（a） might be closely associated with carotid vulnerable plaques. Lowering Lp（a）level was helpful to stabilize the plaque.