GE3.0T磁共振多b值在子宫肌瘤海扶刀治疗评价中的应用研究

Research on Application of GE 3.0T MR DWI Multi b Value in Evaluation of HIFU Treatment for Uterine Fibroids

目的本研究通过分析GE 3.0T核磁子宫肌瘤消融前后的信号特点,比较消融前后子宫肌瘤组织灌注分数,探讨多b值在子宫肌瘤海扶刀(HIFU)治疗中的价值。方法多方位观察T1 FSE、T2 Propeller,多b值扩散加权序列,b=0、50、100、150、200、400、800、1000 s/mm2,LAVAFlex增强。测量治疗前后肌瘤中心的ADC_(slow)、ADC_(fast)及F值。结果治疗后肌瘤组ADCslow较治疗前明显增高,而ADC_(fast)及F值较治疗前明显降低,差异均有统计学意义(P<0.05)。结论利用IVIM的多b值DWI双指数模型,可以在不使用对比剂的情况下对子宫肌瘤的血供情况作出估算,为临床HIFU疗效提供参考。

Objective To analyze the signal characteristics of the pre- and post-ablation of uterine fibroids so as to compare the perfusion fraction of pre- and post-ablation of uterine fibroid tissues and to explore the effectiveness of application of the multi b-value in treatment of uterine fibroids with HIFU（HighIntensity Focused Ultrasound）. Methods T1 FSE, T2 Propeller and multi b-value DWI（DiffusionWeighted Imaging） sequence were observed from multiple azimuths（b=0, 50, 100, 150, 200, 400, 800, 1000 s/mm^2） with LAVA-Flex enhancement. Measurement of pre- and post-treatment ADC_（slow）, ADC_（fast）and F value of the myoma center was made. Results ADC_（slow） in Post-Treatment Group was significantly higher than which in Pre-Treatment Group, while the ADCfast and F value were significantly lower than which in Pre-Treatment Group with statistically significant difference（P0.05）. Conclusion With application of the IVIM DWI b-value double exponential model, the blood supply of uterine fibroids could be estimated without using the contrast agent, which provided reference for clinical HIFU treatment.