比索洛尔对老年心力衰竭患者心功能及NT-proBNP水平的影响

Effect of bisoprolol on cardiac function and the level of NT-proBNP in elderly heart failure

目的:分析比索洛尔对老年心力衰竭患者心功能及N-末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-pro BNP)水平的影响。方法:选取我院2013年4月至2015年4月收治的240例老年心力衰竭患者,按照随机数字表分为观察组及对照组,各120例,均给予血管紧张素转化酶抑制剂、抗血小板、他汀类药物治疗,观察组加用比索洛尔。比较两组患者临床疗效及心功能、NT-pro BNP、血压、心率水平变化。结果:观察组总有效率为86.7%,显著高于对照组的70.8%,差异有统计学意义(P<0.05)。两组患者治疗后左室舒张末期内径(left ventricular enddiastolic dimension,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)、左室舒张末期容积(left ventricular enddiastolic volume,LVEDV)、左室收缩末期容积(left ventricular end systolic diameter,LVES V)、血清NT-pro BNP水平均显著降低,左室射血分数(lef t ventr icular e j ec t i o n f rac t i o n,LV E F)均显著升高,观察组变化更为明显,差异有统计学意义(P<0.0 5)。两组患者治疗后心率、血压均显著降低,观察组心率降低更为明显,差异有统计学意义(P<0.05)。结论:在传统治疗的基础上加用比索洛尔能够进一步降低老年心力衰竭患者血清NT-pro BNP水平,对其心功能的改善具有积极意义。

Objective：To analyze the effects of bisoprolol on cardiac function and N-terminal pro-brain natriuretic peptide （NT-proBNP） level in elderly patients with heart failure.Methods： 240 cases of elderly patients with heart failure in our hospital from April 2013 to April 2015 were randomly divided into observation group and control group, 120 cases for each. They were given angiotensin converting enzyme inhibitors, antiplatelet, statin therapy, etc., the observation group was treated with bisoprolol. hTe clinical effcacy and cardiac function, NT-proBNP, blood pressure and heart rate level in the two groups were compared.Results： hTe total effective rate of the observation group was 86.7%, which was signiifcantly higher than the control group （70.8%）, the difference was statistically signiifcant （P〈0.05）. Atfer treatment, the letf ventricular end-diastolic dimension （LVEDD）, letf ventricular end systolic diameter （LVESD）, letf ventricular enddiastolic volume （LVEDV）, letf ventricular end systolic diameter （LVESV）, serum NT-proBNP level of two groups of patients were significantly lower, left ventricular ejection fraction （LVEF） was signiifcantly higher, the change of observation group was more obvious, the difference was statistically signiifcant （P〈0.05）. hTe heart rate and blood pressure were signiifcantly decreased in the two groups after treatment, and the heart rate of the observation group was more obvious, the difference was statistically significant （P〈0.05）.Conclusion： The basis of conventional treatment combined with bisoprolol can further reduce the level of serum NT-proBNP in elderly patients with heart failure, which has a positive signiifcance to improve heart function.