HPV相关的头颈部鳞状细胞癌的研究进展

Progress of human papillomavirus-related head and neck squamous cell carcinoma

随着吸烟、饮酒危险因素的相应控制,头颈部鳞状细胞癌的发病率有所下降,但是一部分由高危型HPV16/18感染引起的头颈部鳞癌的发病率却呈明显的上升趋势。HPV相关的头颈部鳞癌因特殊的致病因素而表现出独特的基因表达谱和生物学特性,且对放化疗敏感、预后良好以及有更高的生存率,因此治疗方式也有区别于其他头颈部鳞癌。本文就近些年来关于HPV相关的头颈部鳞癌流行病学特点、致癌机制以及诊断与防治作一综述。

The incidence of head and neck squamous cell cancers has declined as the control of traditional risk factors of tobacco and alcohol abuse. However, the incidence of those caused by high risk HPV types 16 and 18 infections has increased obviously. HPV-related head and neck squamous cell cancers display distinct gene expression proifles and biology features. What is more, they are sensitive to radiation chemotherapy and have good prognosis and survival. Hence their treatment is different from other head and neck squamous cell cancers. hTis review is concentrated on the epidemiological characteristics, carcinogenic mechanism and diagnosis and prevention of HPV-related head and neck squamous cell cancers.