154例寻常型银屑病患者骨量检测结果分析

Analyze the result of bone mass with psoriasis vulgaris patients

目的:本研究旨在通过对寻常型银屑病患者代谢的影响因素的分析,探讨骨质疏松与银屑病的关系,为进一步预防及治疗提供依据。方法:本组154例明确诊断寻常型银屑病患者均来自我院皮肤科门诊及住院患者,按不同性别分组,采用双能X线分别检测其腰椎、股骨颈及大转子骨密度,同时记录患者静脉血测定血清钙、磷、碱性磷酸酶、血清骨钙素、25羟维生素D3水平。结果:两组钙、磷、血清碱性磷酸酶无明显差异,女性组血清钙略低于男性组,但无统计学差异,而血清磷水平差异不显著;女性组25羟维生素D3水平均低于男性组,其差异具有统计学意义,女性组血清骨钙素高于男性组,其差异具有统计学意义;两组骨密度比较,女性组均低于男性组,腰椎及股骨颈骨密度差异有统计学意义;股骨颈骨密度降低较明显,其差异具有统计学意义;两组大转子骨密度差异无统计学意义。两组患者按银屑病不同病程,分别统计患者骨量减低及骨质疏松的发病率,男性骨量减低比例较高,发生骨质疏松的比例女性组高于男性组。结论:寻常型银屑病患者骨代谢水平明显下降,且其可能与患者病程有关。

Objective： This study through the analysis of the factors affecting metabolism in patients with psoriasis vulgaris,to explore the relationship between osteoporosis and psoriasis,and to provide the basis for further prevention and treatment.Methods：This group of 154 cases were diagnosed in patients with psoriasis vulgaris were to the outpatient department of Dermatology serf hospital and patients,they were grouped by different gender,using dual energy X-ray were detected in the lumbar spine,femoral neck and trochanter bone mineral density,at the same time, recording and analysis of the venous blood of patients with serum calcium,phosphorus,alkaline phosphatase, osteocalcin,serum 25 hydroxy Vitamin D3.Results：Two groups of calcium,phosphorus,serum alkaline phosphatase showed no significant difference,The serum calcium in female group were slightly lower than the male group,but no statistical difference.There was no significant difference of serum phosphorus;The female group which 25 hydroxy Vitamin D3 levels were lower than the male group,the difference was statistics difference.The female group which serum osteocalcin is higher than the male group, the difference was statistics difference.The bone mineral density were compared by two groups,women＇s groups were lower than the male group,There wre significant differences in BMD in lumbar spine and femoral neck;BMD of femoral neck decreased significantly,the difference was significant. The two groups had no statistically significant difference between the greater troehanter bone density.Two groups of patients with psoriasis in different courses were statistics.The incidence with were counted,Low bone mass of male were higher proportion,The proportion of female group of osteoporosis is higher than the male group.Conclusion： Bone metabolism level were decreased significantly in patients with psoriasis vulgaris;There may be related to the course of patients with psoriasis.