滋阴益气活血膏治疗维持性血透口渴36例疗效观察

Clinical efficacy of yin-nourishing,qi-tonifying,and blood circulation-activating ointment in treatment of thirst in patients undergoing maintenance hemodialysis: a report of 36 cases

目的:观察滋阴益气活血膏治疗血液透析患者口渴的临床疗效。方法:将70例维持性血液透析且伴口渴症状的患者随机分为治疗组36例和对照组34例。治疗组在基础治疗上加服中药滋阴益气活血膏治疗,对照组在基础治疗上加用口香糖咀嚼。观察两组患者治疗前后口渴程度评分、中医证候评分、静息唾液流率及平均透析间期体质量的变化。结果:两组患者治疗前后口渴程度评分、中医证候积分、静息唾液流率、平均透析间期体质量增加百分比组内比较及治疗后组间比较,差异均有统计学意义(P<0.05,P<0.01)。结论:滋阴益气活血膏能改善维持性血液透析患者的口渴症状,且能有效改善患者气阴两虚兼血瘀的症状,增加患者静息唾流率,控制透析间期体质量增加,疗效随疗程增加而增强,值得进一步推广应用。

Objective： To investigate the clinical efficacy of yin- nourishing,qi- tonifying,and blood circulation- activating ointment in the treatment of thirst in patients undergoing maintenance hemodialysis. Methods： A total of70 patients undergoing maintenance hemodialysis and experiencing thirst were randomly divided into treatment group（ n = 36） and control group（ n = 34）. The treatment group received yin- nourishing,qi- tonifying,and blood circulation- activating ointment in addition to the basic treatment,while the control group received chewing gum in addition to the basic treatment. The changes in thirst score,traditional Chinese medicine（ TCM） syndrome score,resting saliva flow rate,and mean interdialytic body weight after treatment were observed in the two groups. Results：After treatment,both groups showed significant improvements in the thirst score,TCM syndrome score,resting saliva flow rate,and mean interdialytic weight gain（ P〈0. 05）. And there were significant differences in the above indices between the two groups after treatment（ P〈0. 01）. Conclusion： Yin- nourishing,qi- tonifying,and blood circulation- activating ointment can improve thirst symptom in patients undergoing maintenance hemodialysis. And it can effectively improve the symptoms due to deficiency of both qi and yin and blood stasis,increase resting saliva flow rate,and control interdialytic weight gain. The efficacy increases with the increasing course of treatment. It holds promise for clinical application.