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The complex contribution of the astrocyte scar

The complex contribution of the astrocyte scar
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摘要 It is tempting to assign positive or negative roles to components of neurotrauma pathology,in an effort to generate an ordered picture and design therapeutic strategies accordingly.However nature is seldom so obliging.This principle is elegantly illustrated in a recent publication from Anderson, It is tempting to assign positive or negative roles to components of neurotrauma pathology,in an effort to generate an ordered picture and design therapeutic strategies accordingly.However nature is seldom so obliging.This principle is elegantly illustrated in a recent publication from Anderson,
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第7期1052-1053,共2页 中国神经再生研究(英文版)
关键词 astrocyte seldom assign picture regeneration illustrated pathology accordingly fibrillary protective astrocyte seldom assign picture regeneration illustrated pathology accordingly fibrillary protective
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参考文献10

  • 1Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV (2016) Astrocyte scar formation aids central nervous system axon regeneration. Nature 532:195-200.
  • 2Huang DW, McKerracher L, Braun PE, David S (1999) A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 24:639-647.
  • 3Liddelow SA, Barres BA (2016) Regeneration: Not everything is scary about a glial scar. Nature 532:182-183.
  • 4Liuzzi FJ, Lasek RJ (1987) Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway. Science 237:642-645.
  • 5Morganti JM, Riparip LK, Rosi S (2016) Call off the Dog(ma): M1/ M2 polarization is concurrent following traumatic brain injury. PLoS One 11:e0148001.
  • 6Neumann S, Woolf CJ (1999) Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23:83-91.
  • 7Piantino J, Burdick JA, Goldberg D, Langer R, Benowitz LI (2006) An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury. Exp Neuro1201:359-367.
  • 8Schwab ME, Thoenen H (1985) Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J Neurosci 5:2415-2423.
  • 9Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5:146-156.
  • 10Silver J, Schwab ME, Popovich PG (2015) Central nervous system regenerative failure: role of oligodendrocytes, astrocytes, and microglia. Cold Spring Harb Perspect Biol 7:a020602.

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