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Mitochondrial translocator protein(TSPO),astrocytes and neuroinflammation 被引量：3

Mitochondrial translocator protein(TSPO),astrocytes and neuroinflammation
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摘要 Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However, Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However,
作者 Olga V.Chechneva Wenbin Deng
机构地区 Department of Biochemistry and Molecular Medicine Institute for Pediatric Regenerative Medicine
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第7期1056-1057,共2页 中国神经再生研究（英文版）
基金 part supported by grants from the National Institutes of Health[R01NS061983,R01ES015988 and R01HD087566)] Shriners Hospitals for Children to WD
关键词 steroids predominantly somewhat synthesizing mitochondrial searching biosynthesis severity macrophages astrocyte steroids predominantly somewhat synthesizing mitochondrial searching biosynthesis severity macrophages astrocyte
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1Banati RB, Middleton RJ, Chan R, Hatty CR, Kam WW, Quin C, Graeber MB, Parmar A, Zahra D, Callaghan P, Fok S, Howell NR, Gregoire M, Szabo A, Pham T, Davis E, Liu GJ (2014) Positron emission tomography and func tional characterization of a complete PBR/TSPO knockout. Nat Commun 5:5452.
  • 2Da Pozzo E, Giacomelli C, Barresi E, Costa B, Taliani S, Passetti Fda S, Martini C (2015 ) Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection. Biochem Soc Trans 43:559-565.
  • 3Daugherty DJ, Chechneva O, Mayrhofer F, Deng W (2016) The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci Rep 6:22556.
  • 4Daugherty DJ, Selvaraj V, Chechneva OV, Liu XB, Pleasure DE, Deng W (2013) A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med 5:891-903.
  • 5Morohaku K, Pelton SH, Daugherty DI, Butler WR, Deng W, Selvaraj V (2014) Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology 155:89-97.
  • 6Ravikumar B, Crawford D, Dellovade T, Savinainen A, Graham D, Liere P, Oudinet JP, Webb M, Hering H (2016) Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of multiple sclerosis. Neuropharmacology 108:229-237.
  • 7Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M (2010) Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov 9:971-988.
  • 8Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7-35.
  • 9Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA (2012) Genomic analysis of reactive astrogliosis. J Neurosci 32:6391-6410.
  • 10Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A (2001) hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31:85-94.

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Neural Regeneration Research
2016年 第7期

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