山羊颞下颌关节盘损伤自我愈合能力的研究

Self-repair capability of surgically created incisions in TMJ disc:An experimental study on goats

目的研究山羊颞下颌关节盘上不同大小的切口的自我愈合能力。方法将30只成年山羊随机分为3组,各组关节盘给予不同大小切口,A组(1mm),B组(3mm),C组(5mm)。术后3月及6月分别将各组中5只山羊处死,通过肉眼观察、组织学及免疫组化检测对关节盘及髁突进行评估。结果 1mm切口的关节盘在术后6个月能自行愈合,肉眼观及组织学形态几乎与正常无异,然而3mm及5mm切口的关节盘却未能愈合,两组中均可见纤维软骨的退行性改变,5mm切口组中程度更为严重。结论山羊的颞下颌关节盘对于较小的切口损伤具有较好自我愈合能力,这为临床上判断颞下颌关节盘穿孔的治疗时机及愈合可能提供了一定的实验依据。

Objective To investigate whether surgically created incisions in discs at different sizes would heal spontaneously. Methods Thirty mature goats were randomly divided into group A（1mm）, group B（3mm） and group C（5mm）according to the length of incision on the discs. Five animals in each group were sacrificed at 3 and 6 months postoperatively. The disc and condyle were evaluated by gross, histological and immunohistochemistry examinations.Results 1-mm discal incisions healed spontaneously with nearly normal gross and histological appearance at 6 months postoperatively, while 3-mm and 5-mm discal incisions failed to heal. Degenerative changes were observed in the fibrocartilage in both 3-mm and 5-mm incision groups, with a greater extent in the 5-mm group. Conclusion the TMJ disc of goat has limited self-repair capability to damage, which will be useful for making pre-surgical decisions related to the size and healing period of TMJ disc perforations.