幽门螺杆菌与胃食管反流病及Barrett食管病变的相关性

Relationship between helicobacter pylori infection and Barrett’s esophagus,gastro-esophageal re-flux disease

目的：探讨幽门螺杆菌（Hp）与 Barrett 食管病变及胃食管反流病的相关性。方法选取2014年1月至2014年9月食管病变患者193例，其中 Barrett 食管病变87例为 Barrett 组，胃食管反流病（ GERD）106例为GERD 组。选取同期食管黏膜正常者60例为对照组。经快速尿素酶法检测 Hp 感染状态。结果 Barrett 食管组、GERD 组、对照组在食管下段的 Hp 感染率分别为41.4％、16.0％、6.7％，Barrett 食管组高于 GERD 组和对照组，差异有统计学意义（P ﹤0.05），GERD 组和对照组比较差异未见统计学意义（P ﹥0.05）。Barrett 食管组、GERD 组、对照组胃窦部的 Hp 感染率分别为43.7％、49.1％、45.0％，三组比较差异未见统计学意义（P ﹥0.05）。结论食管下段 Hp 感染和 Barrett 食管病变相关。

Objective To investigate the relationship between helicobacter pylori（Hp）infection and Barrett’s esophagus,gastro-esophageal reflux disease. Methods From January 2014 to September 2015,193 patients with esophageal diseases were selected,87 cases of Barrett’s esophagus lesions was the Barrett group,106 cases of gastroesophageal reflux disease（GERD）was the GERD group,other 60 cases with normal esophageal mucosa in the same period were selected as the control group. Hp infection status was detected by the rapid urea enzymatic. Results The prevalence of Hp in the lower esophageal of the Barrett group,GERD group,control group was 41. 4% ,16. 0% ,6. 7% ,which of the Barrett group was higher than that of GERD group and control group,the differences was significant（P ﹤ 0. 05）, but there was no difference between the GERD group and control group（P ﹥ 0. 05）. The prevalence of Hp in the gastric antrum in Barrett group,GERD group and control group were 43. 7% ,49. 1% , 45. 0% ,the difference was no significant among the three groups（P ﹥ 0. 05）. Conclusions Hp infec-tion in the lower esophageal is related with the Barrett’s esophagus disease.