重组人表皮生长因子联合复方氯己定防治鼻咽癌放疗性口腔黏膜炎的临床效果

Clinical efficacy of recombinant human epidermal growth factor combined with compound chlo-rine in the prevention and treatment of radiation-induced oral mucositis in nasopharyngeal carci-noma

目的：观察重组人表皮生长因子用于防治鼻咽癌患者放射性口腔黏膜炎的临床疗效。方法选取2013年9月至2014年9月接受治疗的100例鼻咽癌患者为研究对象，随机分为实验组和对照组。对照组常规使用复方氯已定含漱液含漱，实验组自放疗开始使用含漱液含漱后喷重组人表皮生长因子外用液。观察两组患者放射性口腔黏膜炎的发生率、发生时间及疼痛程度，比较分析重组人表皮生长因子对放射性口咽黏膜炎的防治效果。结果实验组口腔黏膜炎发生率低于对照组（P ﹤0.01），口腔黏膜疼痛程度轻于对照组（P ﹤0.05）。结论重组人表皮生长因子含漱可有效降低放射性口腔黏膜炎的发生率，减轻口腔黏膜炎严重程度。

Objective To observe the clinical efficacy of recombinant human epidermal growth factor（rhEGF）in the treatment of radiation-induced oral mucositis in patients with nasopharyngeal carci-noma. Methods One hundred patients with nasopharyngeal carcinoma from September 2013 to Septem-ber 2014 were selected and randomly divided into observation group and control group by numbers. The control group used conventional compound chlorhexidine gargle,meanwhile,the observation group used gargle added rhEGF solution. The incidence of oral mucositis,time of occurrence and degree of pain were observed,and the effect of rhEGF on radiation-induced oral mucositis was compared. Results During the radiotherapy,the degree of radiation-induced oral mucositis（P ﹤ 0. 01）and oral mucosa pain（P ﹤0. 05）in observation group were less than those in control group. Conclusions The rhEGF can effec-tively reduce the incidence of radiation-induced oral mucositis and relieve the oral mucosa pain in the treatment of patients with nasopharyngeal carcinoma.