摘要
巨噬细胞刺激蛋白受体(RON)隶属于原癌基因met家族。目前发现,RON在多种肿瘤存在异常表达。它通过配体结合、受体的过表达和原癌基因变异体的产生,以及激酶区的点突变获得激活,并通过促丝裂原活化蛋白激酶和磷酸肌醇3激酶等信号通路向下游传递,调节细胞增殖、凋亡、迁移与浸润。了解RON在肿瘤发生发展中的作用及其机制以及相关致癌信号途径,能为基于RON的肿瘤靶向治疗提供更多参考。
Recepteur d′origine Nantais(RON),a tyrosine kinase receptor,is a growth factor receptor belonging to the proto-oncogene met family and has been proved to display abnormal expression in many types of tumors. The RON receptor is activated by binding to the ligand macrophage stimulating protein,overexpression of the receptor,variants of the proto-oncogene and by point mutations of the kinase region. The downstream transduction of RON by mitogen-activated protein kinases and phosphoinositide3-kinase signaling pathways can help regulate the proliferation,apoptosis,migration and invasion of tumor cells. A better understanding of the mechanisms and related signaling pathways of RON activation in tumor progress and development will provide more information for the RON-based target therapy.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2016年第7期784-789,共6页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81272828)
浙江省医药卫生科技计划项目(2016KYB263)
宁波市自然科学基金(2015A610224)~~
关键词
酪氨酸激酶
RON
肿瘤
靶向治疗
tyrosine kinase receptor
RON
cancer
target therapy