受体型酪氨酸激酶RON及其在恶性肿瘤发生发展中的作用研究进展

Role of tyrosine kinase receptor RON in tumor growth and metastasis:research progress

巨噬细胞刺激蛋白受体(RON)隶属于原癌基因met家族。目前发现,RON在多种肿瘤存在异常表达。它通过配体结合、受体的过表达和原癌基因变异体的产生,以及激酶区的点突变获得激活,并通过促丝裂原活化蛋白激酶和磷酸肌醇3激酶等信号通路向下游传递,调节细胞增殖、凋亡、迁移与浸润。了解RON在肿瘤发生发展中的作用及其机制以及相关致癌信号途径,能为基于RON的肿瘤靶向治疗提供更多参考。

Recepteur d′origine Nantais（RON）,a tyrosine kinase receptor,is a growth factor receptor belonging to the proto-oncogene met family and has been proved to display abnormal expression in many types of tumors. The RON receptor is activated by binding to the ligand macrophage stimulating protein,overexpression of the receptor,variants of the proto-oncogene and by point mutations of the kinase region. The downstream transduction of RON by mitogen-activated protein kinases and phosphoinositide3-kinase signaling pathways can help regulate the proliferation,apoptosis,migration and invasion of tumor cells. A better understanding of the mechanisms and related signaling pathways of RON activation in tumor progress and development will provide more information for the RON-based target therapy.