麻醉诱导期七氟醚与丙泊酚对自主神经功能影响随机对照评价

Randomized controlled evaluation during anesthesia induction of sevoflurane and propofol on autonomic nervous function

目的探讨麻醉诱导期七氟醚与丙泊酚对自主神经功能的影响。方法将110例择期行手术治疗的患者随机分为两组,每组55例。A组麻醉诱导给予七氟醚,B组给予丙泊酚,观察两组各时间段血压、心率等变化情况。结果 A组麻醉诱导后即刻和插管即刻的呼吸频率及血压低于麻醉前(P<0.05);B组麻醉诱导后即刻、插管即刻、插管后5 min呼吸频率、血压低于麻醉前,且水平低于同时段A组(P<0.05)。A组麻醉后即刻、插管即刻、插管后5 min心率均低于麻醉前,麻醉诱导后即刻、插管即刻高频、低频均低于麻醉前(P<0.05);麻醉前与麻醉后各时间段高低频比值比较(P>0.05)。B组麻醉诱导后即刻至插管后即刻高频、低频均低于麻醉前,麻醉诱导后各时间段高低频比值均高于麻醉前(P<0.05)。结论与丙泊酚相比,采用七氟醚进行麻醉诱导对患者血流动力学的影响较小,诱导相对平稳,利于手术顺利进行。

Objective To explore the sevoflurane and propofol anesthesia induction period effects on autonomic nervous function. Methods 110 patients undergoing elective surgery patients were randomly divided into 2 groups,each group of 55 cases. Induced given sevoflurane anesthesia group A,group B to give propofol,observed two groups of each time period,the change of the blood pressure,heart rate,etc. Results Immediately after anesthesia induction and intubation group A immediate breathing rate,blood pressure was lower than before anesthesia（ P〈0. 05）; Group B immediately after anesthesia induction,immediate intubation,5 min after intubation breathing rate,blood pressure was lower than before anesthesia,and the level was lower than at the same time period of group A（ P〈0. 05）. Immediately after anesthesia in group A,the immediate intubation,5 min after intubation rate were lower than before anesthesia,after anesthesia induction instantly,immediate intubation high frequency and low frequency was lower than before anesthesia（ P〈0. 05）; Before and after the anesthesia,anesthesia times high frequency ratio comparison（ P〈0. 05）. Group B immediately after anesthesia induction and intubation immediately after high frequency and low frequency was lower than before anesthesia,after anesthesia induction times high frequency ratio were higher than anesthesia（ P〈0. 05）. Conclusions Compared with propofol,sevoflurane induction of anesthesia has less influence on hemodynamics of the patients,induced relatively stable,conducive to the operation of smoothly.