微RNA-210研究进展

Research Progress of MicroRNA-210

微RNA(miRNA)是一种内源性的,长度约为22个核苷酸的非编码小RNA分子。miRNA作为翻译抑制因子,介导基因转录后水平的调节,它的发现及研究为揭示体内基因表达调控机制提供了新的思路。迄今为止,已经发现了10 000多种miRNA,其中miR-210因其重要的基因调控作用受到了广泛的关注。在多种肿瘤细胞中均存在miR-210的异常表达,故推测其与肿瘤的发生、发展密切相关。随着研究的深入,miR-210可能成为新的肿瘤标志物及肿瘤基因治疗的新靶点。

MicroRNAs with the length of about 22 nucleotides are a family of small, endogenous, noncoding RNAs. Functioning as post-transcriptional regulators of target genes, rnicroRNAs can degrade the target mRNA after transcription or suppress the gene translation. To date, more than 10000 miRNAs have been found,among which miR-210 is proved as a typically multifunctional miRNA that regulate various physiologi- cal and pathological processes in vivo. Studies found that miR-210 is abnormally expressed in most types of cancer cells, suggesting it might be involved in the occurrence and development of cancer. Therefore, miR-210 is likely to be a novel tumor biomarker and a new target for cancer targeted therapy.