摘要
心血管疾病已成为人类首要的死亡原因,男性是心血管疾病的独立危险因素,提示雄激素在心血管疾病中有重要的作用。雄激素的大部分作用是通过雄激素受体实现的,一方面雄激素可改善脂代谢,促进血压升高,改善胰岛素抵抗,降低血糖水平,间接影响心血管疾病的发生、发展;另一方面雄激素还可调节血管收缩舒张、炎症反应以及内皮和平滑肌细胞的增殖与凋亡,而凝血与纤溶系统则直接参与心血管疾病的调控。
Cardiovascular disease has become the leading cause of death of human. Male gender is an independent risk factor for cardiovascular disease, suggesting that androgens play an important role in cardiovascular disease. Numerous studies show that most of the effects of androgens are realized through binding with androgen receptor. On one hand, androgens can improve lipid metabolism, promote the development of blood pressure, improve insulin resistance and lower blood sugar levels, thus affecting the development of the disease indirectly;on the other hand, androgen can also regulate the development and progression of cardiovascular disease directly through regulating vascular tone, inflammation, proliferation and apoptosis of endothelial and smooth muscle cells,as well as coagulation and fibrinolysis system.
出处
《医学综述》
2016年第15期2928-2931,共4页
Medical Recapitulate
