XPA基因遗传多态性与肺癌易患性关系的Meta分析

XPA Gene Polymorphism and Lung Cancer Susceptibility: A Meta-analysis

目的荟萃分析XPA基因多态性与肺癌易患性关系。方法检索Pubmed、Emlaase、Medline等英文数据库及中国生物医学文献数据库、万方、维普、中国知网等中文数据库中从建库至2015年8月所有有关XPA基因多态性与肺癌易患性相关的病例对照研究，借助Stata13．0统计软件提取数据进行Meta分析。选用OR和95％CI作为合并效应量。结果共12篇文献纳入研究，涉及14项研究，肺癌组4670例，对照组5714例。等位基因AA较等位基因GG增加肺癌的发病风险[AAvsGG：OR=1．177（95％CI1．043～1．327），P=0．008，AAvsAG＋GGIOR=1．219（95％C11．095—1．358），P=0．001]，尤其在亚洲人群、墨西哥裔美国人群及医院人群中差异有统计学意义。结论XPA基因作为肺癌发病的危险因素与肺癌易患性相关。

Objective To meta-analyze the association of the XPA polymorphism with risk of lung cancer. Methods We searched through PubMed, Embase, Medline and China National Knowledge Infra- structure for all eligible studies published up to August 2015. By the aid of Stata 13.0 software, case control studies about the association between XPA and lung cancer were screened out from both English and Chinese database to conduct a recta-analysis. The pooled OR arrd 95% CI were calculated as effect sizes. Results 12 publications about XPA polymorphisms and lung cancer were chosen（ 14 studies ,4670 lung cancer cases and 5714 controls）. Genotype AA increased lung cancer risk[ AA vs GG： OR = 1. 177 （95% CI 1.043- 1. 327 ） ,P = 0. 008, AA vs AG ＋ GG ： OR = 1. 219 （ 95% CI 1. 095-1. 358 ）, P = 0. 001 ], especially in Asians, Mexican-Americans and hospital-based populations. Conclusion XPA polymorphisms are connected with lung cancer susceptibility as independent risk factors.