美罗培南治疗脓毒症休克合并急性肾功能不全的临床研究

Clinical study of meropenem in the treatment of patients with septic shock combined with acute renal insufficiency

目的探讨美罗培南对脓毒症休克合并急性肾功能不全治疗的临床疗效及安全性。方法选择78例脓毒症休克合并急性肾功能不全患者为研究对象,以随机数字表法均分为对照组与观察组;对照组实施常规治疗方案,观察组加用美罗培南治疗,对2组患者治疗后的疗效、血清学指标变化和细菌清除情况进行观察。结果观察组治疗有效率为87.18%,较对照组的有效率71.79%略高(P<0.05);治疗前2组血清学指标无差异,经治疗后2组均出现变化,且观察组与对照组差异有统计学意义(P<0.05);观察组细菌清除率为89.74%,对照组细菌清除率为74.36%(P<0.05)。结论脓毒症休克合并急性肾功能不全患者采取美罗培南治疗可取得与肾脏替代疗效相同的效果,能促进病情恢复,清除细菌感染。

Objective To discuss the clinical effect and safety of meropenem in the treatment of septic shock combined with acute renal insufficiency.Methods 78 cases of patients with septic shock complicated with acute renal insufficiency in our hospital were selected as the study objects.According to random number method,they were divided into 39 cases of the control group,39 cases of the observation group.The control group were given conventional treatment project,while the observation group were given meropenem treatment.The clinical efficacy,the changes of serum parameters,and the bacterial clearance were observed.Results After the treatment,the effective rate of the observation group was 87.18%,higher than 71.79% of the control group（P〈0.05）;there was no difference in serum parameters before the treatment,but the serum index after the treatment had a significant difference（P〈0.05）;the bacterial clearance rate of the 2groups showed that the observation group was 89.74%,and the control group was74.36%（P〈0.05）.Conclusion Patients with septic shock combined with acute renal insufficiency could be treated with meropenem,which can achieve the same effect with renal replacement,and promote the recovery of the disease,clear the bacterial infection.