CRISPR/Cas系统的研究进展及其在畜禽遗传改良中的应用前景

Research Progress in CRISPR/Cas System and the Prospect in Animal Genetic Improvement

广泛存在于细菌和古细菌中的CRISPR/Cas系统是通过介导外源DNA降解来实现抵抗病毒和外源DNA入侵的一种适应性免疫保护机制,也是新近发展起来的基因组定点编辑技术。从基本结构、作用机制、分类、运用等方面详细地介绍了CRISPR/Cas系统,并分析了该技术在畜禽遗传改良中的运用前景。

CRISPR / Cas system widely exists in the bacteria and archaea which is an adaptive immune mechanism of protection by mediating the degradation of exogenous DNA to achieve resistance against invading viruses and exogenous DNA and it is a newly developed genome fixed-point editing techniques. The basic structure,mechanism of action,classification,application and other aspects of the CRISPR / Cas system were introduced,and analyzes the prospect of applying it in animal genetic improvement.