摘要
目的:初步探讨转化生长因子-β1(transforming growth factor-β1,TGF-β1)和表皮生长因子(epidermal growth factor,EGF)在成人增生性瘢痕发生中可能的作用,为临床防治提供一定的依据。方法:通过SP法定性和ELISA法定量检测TGF-β1和EGF在成人增生性瘢痕和成人正常皮肤中的表达情况。结果:TGF-β1、EGF在成人增生性瘢痕中呈高表达,二者在成人增生性瘢痕中表达水平呈正相关。结论:TGF-β1、EGF在成人增生性瘢痕中均呈高表达,TGF-β1和EGF在成人增生性瘢痕中的表达水平呈正相关,这为研究临床预防、治疗皮肤增生性瘢痕提供新思路。
Objective：To investigate transforming growth factor-β1 （TGF-β1） and epidermal growth facto （EGF） in aduhs hy- pertrophic scars occurred in possible role, to provide basis for clinical prevention. Methods：The expression of TGF-β1 and EGF in adult hypertrophic scar and adult normal skin was quantitatively detected by SP and ELISA methods. Results：TGF-β1 ,EGF in adults hyper- trophic scars showed high expression,both expressed in adult hyperplastic scar levels were positively correlated. Conclusion：TGF-β1, EGF in adults hypertrophic scars showed high expression,TGF-β1 and EGF expression levels in adult hypertrophic scars were positively correlated, which provide new ideas for clinical prevention and treatment of skin hypertrophic scars.
出处
《川北医学院学报》
CAS
2016年第4期548-552,共5页
Journal of North Sichuan Medical College
基金
四川省卫生发展研究中心项目(SJWF1311)
