早期血液灌流对老年急性有机磷中毒的临床疗效分析

Analysis of Clinical effect of early hemoperfusion on acute organophosphorus poisoning in elderly patients

目的：分析早期血液灌流（hemoperfusion,HP）对老年急性有机磷中毒的临床疗效。方法：收集2009年1月至2014年1月在我院接受治疗的老年急性有机磷中毒的患者76例;依据患者接受HP的时间,将76例患者分为观察组（≤8 h）及对照组（〉8 h）,分别为37例和39例。结果：观察组患者痊愈率显著高于对照组（χ2=4.214,P=0.040）;观察组死亡率显著低于对照组（χ2=5.074,P=0.024）;观察组患者发生ARDS的比例显著低于对照组（χ2=4.116,P=0.043）;入院3 d以后,观察组患者全血ACh E活力显著高于对照组（P〈0.01）。结论：HP对老年急性有机磷中毒的临床疗效可靠,且早期实施治疗可进一步提高疗效。

Objective：To analyse clinical effect of early hemoperfusion（HP） on acute organophosphorus poisoning in elderly patients. Methods：76 cases of senile acute organophosphorus poisoning in our hospital from January 2009 to January 2014 were selected;According to the time of receiving HP,76 cases was divided into observation group（ ≤8 h,37 cases） and control group（ 〉 8 h,39 cases）. Results ：The cure rate of the observation group was significantly higher than that of the control group （X2 = 5. 074, P = 0. 024 ） ; The mortality of the observation group was significantly lower than that of the control group（x2 = 5. 074,P = 0. 024） ;the proportion of ARDS in the observation group was significantly lower than that in the control group（x^2 = 4. 116,P = 0. 043 ） ;3 days after admission, the AChE activities in blood of the observation group was significantly higher than that of the control group（P 〈 0.01 ）. Conclusion： The Clinical effect of HP on senile acute organophosphorus poisoning is reliable,and the efficacy can be improved with early implementation.